TY - JOUR
T1 - Functional aspects of free muscle transplantation
T2 - Atrophy, reinnervation, and metabolism
AU - Wolff, K. D.
AU - Stiller, D.
PY - 1992
Y1 - 1992
N2 - The atrophy, reinnervation, and metabolism of free muscle flaps were studied in a rat model, by syngeneic and orthotopic transplantation of abdominal wall muscle flaps with neurovascular anastomoses. The three parameters were examined at different time periods, using electrophysiologic and 31-P-spectroscopic measurements. Results show that a certain degree of atrophy (one-fifth of the original volume) must be expected, even when new axons grow throughout the nerve. This is explained by the early reduction of flap metabolism, leading to a loss of parenchyma until neuromuscular conduction is restored. As the maximum duration of ischemia is 2 hr, muscular damage due to reduced metabolism was not produced.
AB - The atrophy, reinnervation, and metabolism of free muscle flaps were studied in a rat model, by syngeneic and orthotopic transplantation of abdominal wall muscle flaps with neurovascular anastomoses. The three parameters were examined at different time periods, using electrophysiologic and 31-P-spectroscopic measurements. Results show that a certain degree of atrophy (one-fifth of the original volume) must be expected, even when new axons grow throughout the nerve. This is explained by the early reduction of flap metabolism, leading to a loss of parenchyma until neuromuscular conduction is restored. As the maximum duration of ischemia is 2 hr, muscular damage due to reduced metabolism was not produced.
UR - http://www.scopus.com/inward/record.url?scp=0026550943&partnerID=8YFLogxK
U2 - 10.1055/s-2007-1006696
DO - 10.1055/s-2007-1006696
M3 - Article
C2 - 1532986
AN - SCOPUS:0026550943
SN - 0743-684X
VL - 8
SP - 137
EP - 142
JO - Journal of Reconstructive Microsurgery
JF - Journal of Reconstructive Microsurgery
IS - 2
ER -