Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)

Mridul Agrawal; Peggy Schwarz; Benedetto Daniele Giaimo; Ivan Bedzhov; Andrea Corbacioglu; Daniela Weber; Verena I. Gaidzik; Nikolaus Jahn; Frank G. Rücker; Thomas Schroeder; Thomas Kindler; Mohammed Wattad; Katharina Götze; Michael Lübbert; Hans Salwender; Mark Ringhoffer; Elisabeth Lange; Elisabeth Koller; Felicitas Thol; Michael Heuser; Arnold Ganser; Lars Bullinger; Peter Paschka; Hartmut Döhner; Hartmut Geiger; Tilman Borggrefe; Konstanze Döhner; Franz Oswald

doi:10.1038/s41375-019-0551-4

Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)

Mridul Agrawal, Peggy Schwarz, Benedetto Daniele Giaimo, Ivan Bedzhov, Andrea Corbacioglu, Daniela Weber, Verena I. Gaidzik, Nikolaus Jahn, Frank G. Rücker, Thomas Schroeder, Thomas Kindler, Mohammed Wattad, Katharina Götze, Michael Lübbert, Hans Salwender, Mark Ringhoffer, Elisabeth Lange, Elisabeth Koller, Felicitas Thol, Michael HeuserArnold Ganser, Lars Bullinger, Peter Paschka, Hartmut Döhner, Hartmut Geiger, Tilman Borggrefe, Konstanze Döhner, Franz Oswald

Department of Internal Medicine III - Hematology and Medical Oncology

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Original language	English
Pages (from-to)	630-634
Number of pages	5
Journal	Leukemia
Volume	34
Issue number	2
DOIs	https://doi.org/10.1038/s41375-019-0551-4
State	Published - 1 Feb 2020

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Agrawal, M., Schwarz, P., Giaimo, B. D., Bedzhov, I., Corbacioglu, A., Weber, D., Gaidzik, V. I., Jahn, N., Rücker, F. G., Schroeder, T., Kindler, T., Wattad, M., Götze, K., Lübbert, M., Salwender, H., Ringhoffer, M., Lange, E., Koller, E., Thol, F., ... Oswald, F. (2020). Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML). Leukemia, 34(2), 630-634. https://doi.org/10.1038/s41375-019-0551-4

@article{fd3fc8e29d724557b016725e13b3ade0,

title = "Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)",

author = "Mridul Agrawal and Peggy Schwarz and Giaimo, {Benedetto Daniele} and Ivan Bedzhov and Andrea Corbacioglu and Daniela Weber and Gaidzik, {Verena I.} and Nikolaus Jahn and R{\"u}cker, {Frank G.} and Thomas Schroeder and Thomas Kindler and Mohammed Wattad and Katharina G{\"o}tze and Michael L{\"u}bbert and Hans Salwender and Mark Ringhoffer and Elisabeth Lange and Elisabeth Koller and Felicitas Thol and Michael Heuser and Arnold Ganser and Lars Bullinger and Peter Paschka and Hartmut D{\"o}hner and Hartmut Geiger and Tilman Borggrefe and Konstanze D{\"o}hner and Franz Oswald",

note = "Funding Information: Acknowledgements We are grateful to Drs. H. Jumaa, M. Bach, E. Surova and M. Stemmler for sharing reagents and knowledge. We want to thank E. Lopez and Dr. B. Kanzler from the Transgenic Mouse Unit of the Max Planck Institute in Freiburg (Germany) for the generation of the knock-in mice. This work was in part supported by the collaborative research grant TRR81 and BO 1639/9-1 by the DFG (German Research Foundation), the Max Planck Society and the EXC 294 in Freiburg and the Excellence Cluster for Cardio Pulmonary System (ECCPS) in Giessen to TB. BDG is supported by a Research Grant of the University Medical Center Giessen and Marburg (UKGM). This study was supported in part by the Excellence Initiative of the German Federal and State Governments (GSC-4, Spemann Graduate School). This study was additionally supported in part by the Deutsche Forschungsgemeinschaft (SFB 1074 project; subproject A3 and B3). MA was supported by the Else Kr{\"o}ner-Forschungskolleg and the Deutsche Forschungsgemeinschaft (DFG, AG252/1-1). We greatly acknowledge the members of the German-Austrian AML Study Group (AMLSG) for providing patient samples and clinical information.",

year = "2020",

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doi = "10.1038/s41375-019-0551-4",

language = "English",

volume = "34",

pages = "630--634",

journal = "Leukemia",

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Agrawal, M, Schwarz, P, Giaimo, BD, Bedzhov, I, Corbacioglu, A, Weber, D, Gaidzik, VI, Jahn, N, Rücker, FG, Schroeder, T, Kindler, T, Wattad, M, Götze, K, Lübbert, M, Salwender, H, Ringhoffer, M, Lange, E, Koller, E, Thol, F, Heuser, M, Ganser, A, Bullinger, L, Paschka, P, Döhner, H, Geiger, H, Borggrefe, T, Döhner, K & Oswald, F 2020, 'Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)', Leukemia, vol. 34, no. 2, pp. 630-634. https://doi.org/10.1038/s41375-019-0551-4

TY - JOUR

T1 - Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)

AU - Agrawal, Mridul

AU - Schwarz, Peggy

AU - Giaimo, Benedetto Daniele

AU - Bedzhov, Ivan

AU - Corbacioglu, Andrea

AU - Weber, Daniela

AU - Gaidzik, Verena I.

AU - Jahn, Nikolaus

AU - Rücker, Frank G.

AU - Schroeder, Thomas

AU - Kindler, Thomas

AU - Wattad, Mohammed

AU - Götze, Katharina

AU - Lübbert, Michael

AU - Salwender, Hans

AU - Ringhoffer, Mark

AU - Lange, Elisabeth

AU - Koller, Elisabeth

AU - Thol, Felicitas

AU - Heuser, Michael

AU - Ganser, Arnold

AU - Bullinger, Lars

AU - Paschka, Peter

AU - Döhner, Hartmut

AU - Geiger, Hartmut

AU - Borggrefe, Tilman

AU - Döhner, Konstanze

AU - Oswald, Franz

N1 - Funding Information: Acknowledgements We are grateful to Drs. H. Jumaa, M. Bach, E. Surova and M. Stemmler for sharing reagents and knowledge. We want to thank E. Lopez and Dr. B. Kanzler from the Transgenic Mouse Unit of the Max Planck Institute in Freiburg (Germany) for the generation of the knock-in mice. This work was in part supported by the collaborative research grant TRR81 and BO 1639/9-1 by the DFG (German Research Foundation), the Max Planck Society and the EXC 294 in Freiburg and the Excellence Cluster for Cardio Pulmonary System (ECCPS) in Giessen to TB. BDG is supported by a Research Grant of the University Medical Center Giessen and Marburg (UKGM). This study was supported in part by the Excellence Initiative of the German Federal and State Governments (GSC-4, Spemann Graduate School). This study was additionally supported in part by the Deutsche Forschungsgemeinschaft (SFB 1074 project; subproject A3 and B3). MA was supported by the Else Kröner-Forschungskolleg and the Deutsche Forschungsgemeinschaft (DFG, AG252/1-1). We greatly acknowledge the members of the German-Austrian AML Study Group (AMLSG) for providing patient samples and clinical information.

PY - 2020/2/1

Y1 - 2020/2/1

UR - http://www.scopus.com/inward/record.url?scp=85071911819&partnerID=8YFLogxK

U2 - 10.1038/s41375-019-0551-4

DO - 10.1038/s41375-019-0551-4

M3 - Letter

C2 - 31462736

AN - SCOPUS:85071911819

SN - 0887-6924

VL - 34

SP - 630

EP - 634

JO - Leukemia

JF - Leukemia

IS - 2

ER -

Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)

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