Functional adaptation of BabA the H. pylori ABO blood group antigen binding adhesin

Marina Aspholm-Hurtig; Giedrius Dailide; Martina Lahmann; Awdhesh Kalia; Dag Ilver; Niamh Roche; Susanne Vikström; Rolf Sjöström; Sara Lindén; Anna Bäckström; Carina Lundberg; Anna Arnqvist; Jafar Mahdavi; Ulf J. Nilsson; Billie Velapatño; Robert H. Gilman; Markus Gerhard; Teresa Alarcon; Manuel López-Brea; Teruko Nakazawa; James G. Fox; Pelayo Correa; Maria Gloria Dominguez-Bello; Guillermo I. Perez-Perez; Martin J. Blaser; Staffan Normark; Ingemar Carlstedt; Stefan Oscarson; Susann Teneberg; Douglas E. Berg; Thomas Borén

doi:10.1126/science.1098801

Functional adaptation of BabA the H. pylori ABO blood group antigen binding adhesin

Marina Aspholm-Hurtig, Giedrius Dailide, Martina Lahmann, Awdhesh Kalia, Dag Ilver, Niamh Roche, Susanne Vikström, Rolf Sjöström, Sara Lindén, Anna Bäckström, Carina Lundberg, Anna Arnqvist, Jafar Mahdavi, Ulf J. Nilsson, Billie Velapatño, Robert H. Gilman, Markus Gerhard, Teresa Alarcon, Manuel López-Brea, Teruko NakazawaJames G. Fox, Pelayo Correa, Maria Gloria Dominguez-Bello, Guillermo I. Perez-Perez, Martin J. Blaser, Staffan Normark, Ingemar Carlstedt, Stefan Oscarson, Susann Teneberg, Douglas E. Berg, Thomas Borén

Associate Professorship of Medical Microbiology and Immunology

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337 Scopus citations

Abstract

Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.

Original language	English
Pages (from-to)	519-522
Number of pages	4
Journal	Science
Volume	305
Issue number	5683
DOIs	https://doi.org/10.1126/science.1098801
State	Published - 23 Jul 2004

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Aspholm-Hurtig, M., Dailide, G., Lahmann, M., Kalia, A., Ilver, D., Roche, N., Vikström, S., Sjöström, R., Lindén, S., Bäckström, A., Lundberg, C., Arnqvist, A., Mahdavi, J., Nilsson, U. J., Velapatño, B., Gilman, R. H., Gerhard, M., Alarcon, T., López-Brea, M., ... Borén, T. (2004). Functional adaptation of BabA the H. pylori ABO blood group antigen binding adhesin. Science, 305(5683), 519-522. https://doi.org/10.1126/science.1098801

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title = "Functional adaptation of BabA the H. pylori ABO blood group antigen binding adhesin",

abstract = "Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.",

author = "Marina Aspholm-Hurtig and Giedrius Dailide and Martina Lahmann and Awdhesh Kalia and Dag Ilver and Niamh Roche and Susanne Vikstr{\"o}m and Rolf Sj{\"o}str{\"o}m and Sara Lind{\'e}n and Anna B{\"a}ckstr{\"o}m and Carina Lundberg and Anna Arnqvist and Jafar Mahdavi and Nilsson, {Ulf J.} and Billie Velapat{\~n}o and Gilman, {Robert H.} and Markus Gerhard and Teresa Alarcon and Manuel L{\'o}pez-Brea and Teruko Nakazawa and Fox, {James G.} and Pelayo Correa and Dominguez-Bello, {Maria Gloria} and Perez-Perez, {Guillermo I.} and Blaser, {Martin J.} and Staffan Normark and Ingemar Carlstedt and Stefan Oscarson and Susann Teneberg and Berg, {Douglas E.} and Thomas Bor{\'e}n",

year = "2004",

month = jul,

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doi = "10.1126/science.1098801",

language = "English",

volume = "305",

pages = "519--522",

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Aspholm-Hurtig, M, Dailide, G, Lahmann, M, Kalia, A, Ilver, D, Roche, N, Vikström, S, Sjöström, R, Lindén, S, Bäckström, A, Lundberg, C, Arnqvist, A, Mahdavi, J, Nilsson, UJ, Velapatño, B, Gilman, RH, Gerhard, M, Alarcon, T, López-Brea, M, Nakazawa, T, Fox, JG, Correa, P, Dominguez-Bello, MG, Perez-Perez, GI, Blaser, MJ, Normark, S, Carlstedt, I, Oscarson, S, Teneberg, S, Berg, DE & Borén, T 2004, 'Functional adaptation of BabA the H. pylori ABO blood group antigen binding adhesin', Science, vol. 305, no. 5683, pp. 519-522. https://doi.org/10.1126/science.1098801

TY - JOUR

T1 - Functional adaptation of BabA the H. pylori ABO blood group antigen binding adhesin

AU - Aspholm-Hurtig, Marina

AU - Dailide, Giedrius

AU - Lahmann, Martina

AU - Kalia, Awdhesh

AU - Ilver, Dag

AU - Roche, Niamh

AU - Vikström, Susanne

AU - Sjöström, Rolf

AU - Lindén, Sara

AU - Bäckström, Anna

AU - Lundberg, Carina

AU - Arnqvist, Anna

AU - Mahdavi, Jafar

AU - Nilsson, Ulf J.

AU - Velapatño, Billie

AU - Gilman, Robert H.

AU - Gerhard, Markus

AU - Alarcon, Teresa

AU - López-Brea, Manuel

AU - Nakazawa, Teruko

AU - Fox, James G.

AU - Correa, Pelayo

AU - Dominguez-Bello, Maria Gloria

AU - Perez-Perez, Guillermo I.

AU - Blaser, Martin J.

AU - Normark, Staffan

AU - Carlstedt, Ingemar

AU - Oscarson, Stefan

AU - Teneberg, Susann

AU - Berg, Douglas E.

AU - Borén, Thomas

PY - 2004/7/23

Y1 - 2004/7/23

N2 - Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.

AB - Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.

UR - http://www.scopus.com/inward/record.url?scp=3242748894&partnerID=8YFLogxK

U2 - 10.1126/science.1098801

DO - 10.1126/science.1098801

M3 - Article

C2 - 15273394

AN - SCOPUS:3242748894

SN - 0036-8075

VL - 305

SP - 519

EP - 522

JO - Science

JF - Science

IS - 5683

ER -

Functional adaptation of BabA the H. pylori ABO blood group antigen binding adhesin

Abstract

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