From virus to inflammation: Mechanisms of RIG-I-induced IL-1β production

Hendrik Poeck, Jürgen Ruland

Research output: Contribution to journalShort surveypeer-review

38 Scopus citations

Abstract

Early detection of viruses by the innate immune system is critical for host defense. Antiviral immunity is initiated by germline encoded pattern recognition receptors (PRRs) that recognize viral pathogen-associated molecular patterns (PAMPs) such as nucleic acids. Intracellular PRRs then drive the production of interferons and cytokines to orchestrate immune responses. One key host factor that is critical for antiviral immunity and for systemic inflammatory reactions including fever is interleukin-1beta (IL-1β). Here we discuss current insights into the molecular mechanisms how the cytosolic RNA helicase RIG-I triggers NF-κB signaling and inflammasome activation specifically for RNA virus-induced IL-1β production.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalEuropean Journal of Cell Biology
Volume91
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • CARD9
  • IL-1β
  • Inflammasome
  • NLRP3
  • NOD like receptors
  • RIG-I-like helicases

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