From developmental biology to developmental toxicology

R. Balling, M. H. De Angelis

Research output: Contribution to journalArticlepeer-review


Progress derived from the human genome project will have tremendous impact on toxicology. Questions concerning genetic susceptibility or resistance to toxic compound exposure and the dissection of the molecular mechanisms involved will be at the forefront of future toxicological research. In recent years, it was recognized that many of the molecular control mechanisms of embryogenesis have been conserved during evolution. The relevance of these observations for toxicology and the application of genetic approaches using mouse mutants as a tool for functional genome analysis are discussed.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalAnnals of the New York Academy of Sciences
StatePublished - 2000
Externally publishedYes


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