Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

Manuel Schottdorf, Boris Hofmann, Enno Kätelhön, Andreas Offenhäusser, Bernhard Wolfrum

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We present a model to describe the response of chip-based nanocavity sensors during extracellular recording of action potentials. These sensors feature microelectrodes which are embedded in liquid-filled cavities. They can be used for the highly localized detection of electrical signals on a chip. We calculate the sensor's impedance and simulate the propagation of action potentials. Subsequently we apply our findings to analyze cell-chip coupling properties. The results are compared to experimental data obtained from cardiomyocyte-like cells. We show that both the impedance and the modeled action potentials fit the experimental data well. Furthermore, we find evidence for a large seal resistance of cardiomyocytes on nanocavity sensors compared to conventional planar recording systems.

Original languageEnglish
Article number031917
JournalPhysical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
Volume85
Issue number3
DOIs
StatePublished - 29 Mar 2012
Externally publishedYes

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