TY - JOUR
T1 - Framework and baseline examination of the German National Cohort (NAKO)
AU - German National Cohort (NAKO) Consortium
AU - Peters, Annette
AU - Greiser, Karin Halina
AU - Göttlicher, Susanne
AU - Ahrens, Wolfgang
AU - Albrecht, Maren
AU - Bamberg, Fabian
AU - Bärnighausen, Till
AU - Becher, Heiko
AU - Berger, Klaus
AU - Beule, Achim
AU - Boeing, Heiner
AU - Bohn, Barbara
AU - Bohnert, Kerstin
AU - Braun, Bettina
AU - Brenner, Hermann
AU - Bülow, Robin
AU - Castell, Stefanie
AU - Damms-Machado, Antje
AU - Dörr, Marcus
AU - Ebert, Nina
AU - Ecker, Margit
AU - Emmel, Carina
AU - Fischer, Beate
AU - Franzke, Claus Werner
AU - Gastell, Sylvia
AU - Giani, Guido
AU - Günther, Matthias
AU - Günther, Kathrin
AU - Günther, Klaus Peter
AU - Haerting, Johannes
AU - Haug, Ulrike
AU - Heid, Iris M.
AU - Heier, Margit
AU - Heinemeyer, Diana
AU - Hendel, Thomas
AU - Herbolsheimer, Florian
AU - Hirsch, Jochen
AU - Hoffmann, Wolfgang
AU - Holleczek, Bernd
AU - Hölling, Heike
AU - Hörlein, Andreas
AU - Jöckel, Karl Heinz
AU - Kaaks, Rudolf
AU - Karch, André
AU - Karrasch, Stefan
AU - Kartschmit, Nadja
AU - Kauczor, Hans Ulrich
AU - Keil, Thomas
AU - Kemmling, Yvonne
AU - Schmidt, Georg
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/10/1
Y1 - 2022/10/1
N2 - The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection and prevention of disease. Specifically, NAKO is designed to identify novel and better characterize established risk and protection factors for the development of cardiovascular diseases, cancer, diabetes, neurodegenerative and psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases in a random sample of the general population. Between 2014 and 2019, a total of 205,415 men and women aged 19–74 years were recruited and examined in 18 study centres in Germany. The baseline assessment included a face-to-face interview, self-administered questionnaires and a wide range of biomedical examinations. Biomaterials were collected from all participants including serum, EDTA plasma, buffy coats, RNA and erythrocytes, urine, saliva, nasal swabs and stool. In 56,971 participants, an intensified examination programme was implemented. Whole-body 3T magnetic resonance imaging was performed in 30,861 participants on dedicated scanners. NAKO collects follow-up information on incident diseases through a combination of active follow-up using self-report via written questionnaires at 2–3 year intervals and passive follow-up via record linkages. All study participants are invited for re-examinations at the study centres in 4–5 year intervals. Thereby, longitudinal information on changes in risk factor profiles and in vascular, cardiac, metabolic, neurocognitive, pulmonary and sensory function is collected. NAKO is a major resource for population-based epidemiology to identify new and tailored strategies for early detection, prediction, prevention and treatment of major diseases for the next 30 years.
AB - The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection and prevention of disease. Specifically, NAKO is designed to identify novel and better characterize established risk and protection factors for the development of cardiovascular diseases, cancer, diabetes, neurodegenerative and psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases in a random sample of the general population. Between 2014 and 2019, a total of 205,415 men and women aged 19–74 years were recruited and examined in 18 study centres in Germany. The baseline assessment included a face-to-face interview, self-administered questionnaires and a wide range of biomedical examinations. Biomaterials were collected from all participants including serum, EDTA plasma, buffy coats, RNA and erythrocytes, urine, saliva, nasal swabs and stool. In 56,971 participants, an intensified examination programme was implemented. Whole-body 3T magnetic resonance imaging was performed in 30,861 participants on dedicated scanners. NAKO collects follow-up information on incident diseases through a combination of active follow-up using self-report via written questionnaires at 2–3 year intervals and passive follow-up via record linkages. All study participants are invited for re-examinations at the study centres in 4–5 year intervals. Thereby, longitudinal information on changes in risk factor profiles and in vascular, cardiac, metabolic, neurocognitive, pulmonary and sensory function is collected. NAKO is a major resource for population-based epidemiology to identify new and tailored strategies for early detection, prediction, prevention and treatment of major diseases for the next 30 years.
KW - Communicable diseases
KW - Epidemiology
KW - Functional impairments
KW - Life-style and socio-economic factors
KW - Magnetic resonance imaging
KW - Non-communicable diseases
KW - Population-based cohort
KW - Pre-clinical disease
KW - Psychosocial factors
UR - http://www.scopus.com/inward/record.url?scp=85131637626&partnerID=8YFLogxK
U2 - 10.1007/s10654-022-00890-5
DO - 10.1007/s10654-022-00890-5
M3 - Article
C2 - 36260190
AN - SCOPUS:85131637626
SN - 0393-2990
VL - 37
SP - 1107
EP - 1124
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 10
ER -