Food-grade synthesis of Maillard-type taste enhancers using natural deep eutectic solvents (NADES)

Maximilian Kranz, Thomas Hofmann

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The increasing demand for healthier food products, with reduced levels of table salt, sugar, and mono sodium glutamate, reinforce the need for novel taste enhancers prepared by means of food-grade kitchen-type chemistry. Although several taste modulating compounds have been discovered in processed foods, their Maillard-type ex food production is usually not exploited by industrial process reactions as the yields of target compounds typically do not exceed 1-2%. Natural deep eutectic solvents (NADES) are reported for the first time to significantly increase the yields of the taste enhancers 1-deoxy-D-fructosyl-N-ß-alanyl-L-histidine (49% yield), N-(1-methyl-4-oxoimidazolidin-2-ylidene) aminopropionic acid (54% yield) and N2-(1-carboxyethyl) guanosine 5'-monophosphate (22% yield) at low temperature (80-100 °C) within a maximum reaction time of 2 h. Therefore, NADES open new avenues to a "next-generation culinary chemistry" overcoming the yield limitations of traditional Maillard chemistry approaches and enable a food-grade Maillardtype generation of flavor modulators.

Original languageEnglish
Article number261
Issue number2
StatePublished - 2018


  • Amadori rearrangement
  • Food-grade synthesis
  • Green chemistry
  • Maillard reaction
  • Taste enhancers


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