Focal encephalitis in the Lewis rat induced by intracerebral enterotoxin superantigen and amplified by activated intravenous splenocytes

Malte E. Kornhuber, Caroline Ganz, Roland Lang, Thomas Brill, Wolfgang Schmahl

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The histological response after intracerebral (IC) injection of superantigen (SAg) was investigated in unprimed Lewis rats. The staphylococcal enterotoxins (SE) A (SEA), and E, but not B or saline, induced a variable perivascular inflammation in the injected hemisphere (6.7±6.1 cuffs per tissue section with SEA; mean±SD). Adoptive transfer of mitogen activated splenocytes (AS) augmented the response to SEA significantly (18.5±11.4; P<0.05). With or without AS transient bilateral perivascular cuffs were observed around the ventricles and in the corpus callosum up to 3 days after IC injection. The findings demonstrate that local expression of SAg in the brain can cause encephalitis, depending on the number of activated T cells in the circulation.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalNeuroscience Letters
Volume324
Issue number2
DOIs
StatePublished - 17 May 2002
Externally publishedYes

Keywords

  • Encephalitis
  • Experimental allergic encephalitis
  • Lymphocyte migration
  • Multiple sclerosis
  • Rat
  • Staphylococcal enterotoxin
  • Superantigen

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