Fluorescent Polyvinylphosphonate Bioconjugates for Selective Cellular Delivery

Christina Schwarzenböck, Andreas Schaffer, Elfriede Nößner, Peter J. Nelson, Ralf Huss, Bernhard Rieger

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

To date, many poly(ethylene glycol) (PEG) and poly(N-isopropylacrylamide) (PNIPAAm) biomolecule conjugates have been described, but they often show long response times, are not bio-inert, or lose function in biological fluids. Herein, we present a modular synthetic approach to generate polyvinylphosphonate biomolecule conjugates. These conjugates exhibit a sharp phase transition temperature even under physiological conditions where few other examples with this property have been described to date. Furthermore, it was feasible to add biological functions to the polymers via the conjugation step. The polyvinylphosphonate cholesterol constructs are attached to the cellular membrane and the folic acid anchored polymers are shuttled into the cells. This is an exceptional finding through a straightforward synthetic approach.

Original languageEnglish
Pages (from-to)2584-2587
Number of pages4
JournalChemistry - A European Journal
Volume24
Issue number11
DOIs
StatePublished - 21 Feb 2018

Keywords

  • delivery
  • fluorescent polymer bioconjugate
  • selective cellular targeting
  • thermoresponsive polymer
  • thiol-ene click chemistry

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