TY - JOUR
T1 - Fluorescent Polyvinylphosphonate Bioconjugates for Selective Cellular Delivery
AU - Schwarzenböck, Christina
AU - Schaffer, Andreas
AU - Nößner, Elfriede
AU - Nelson, Peter J.
AU - Huss, Ralf
AU - Rieger, Bernhard
N1 - Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/2/21
Y1 - 2018/2/21
N2 - To date, many poly(ethylene glycol) (PEG) and poly(N-isopropylacrylamide) (PNIPAAm) biomolecule conjugates have been described, but they often show long response times, are not bio-inert, or lose function in biological fluids. Herein, we present a modular synthetic approach to generate polyvinylphosphonate biomolecule conjugates. These conjugates exhibit a sharp phase transition temperature even under physiological conditions where few other examples with this property have been described to date. Furthermore, it was feasible to add biological functions to the polymers via the conjugation step. The polyvinylphosphonate cholesterol constructs are attached to the cellular membrane and the folic acid anchored polymers are shuttled into the cells. This is an exceptional finding through a straightforward synthetic approach.
AB - To date, many poly(ethylene glycol) (PEG) and poly(N-isopropylacrylamide) (PNIPAAm) biomolecule conjugates have been described, but they often show long response times, are not bio-inert, or lose function in biological fluids. Herein, we present a modular synthetic approach to generate polyvinylphosphonate biomolecule conjugates. These conjugates exhibit a sharp phase transition temperature even under physiological conditions where few other examples with this property have been described to date. Furthermore, it was feasible to add biological functions to the polymers via the conjugation step. The polyvinylphosphonate cholesterol constructs are attached to the cellular membrane and the folic acid anchored polymers are shuttled into the cells. This is an exceptional finding through a straightforward synthetic approach.
KW - delivery
KW - fluorescent polymer bioconjugate
KW - selective cellular targeting
KW - thermoresponsive polymer
KW - thiol-ene click chemistry
UR - http://www.scopus.com/inward/record.url?scp=85041019076&partnerID=8YFLogxK
U2 - 10.1002/chem.201706034
DO - 10.1002/chem.201706034
M3 - Article
C2 - 29315897
AN - SCOPUS:85041019076
SN - 0947-6539
VL - 24
SP - 2584
EP - 2587
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 11
ER -