TY - JOUR
T1 - Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws
AU - Pautke, Christoph
AU - Bauer, Florian
AU - Tischer, Thomas
AU - Kreutzer, Kilian
AU - Weitz, Jochen
AU - Kesting, Marco
AU - Hölzle, Frank
AU - Kolk, Andreas
AU - Stürzenbaum, Stephen R.
AU - Wolff, Klaus Dietrich
PY - 2009/3
Y1 - 2009/3
N2 - Purpose: To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ. Patients and Methods: Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm. Results: Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence. Conclusion: In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.
AB - Purpose: To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ. Patients and Methods: Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm. Results: Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence. Conclusion: In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.
UR - http://www.scopus.com/inward/record.url?scp=60249089331&partnerID=8YFLogxK
U2 - 10.1016/j.joms.2008.09.037
DO - 10.1016/j.joms.2008.09.037
M3 - Article
C2 - 19231768
AN - SCOPUS:60249089331
SN - 0278-2391
VL - 67
SP - 471
EP - 476
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 3
ER -