Fluconazole penetration into the pancreas

S. Shrikhande; H. Friess; C. Issenegger; M. E. Martignoni; H. Yong; B. Gloor; R. Yeates; J. Kleeff; M. W. Buchler

doi:10.1128/AAC.44.9.2569-2571.2000

Fluconazole penetration into the pancreas

S. Shrikhande, H. Friess, C. Issenegger, M. E. Martignoni, H. Yong, B. Gloor, R. Yeates, J. Kleeff, M. W. Buchler

University of Bern

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis. In human pancreatic tissues, the mean fluconazole concentration was 8.19 ± 3.38 μg/g (96% of the corresponding concentration in serum). In experimental edematous and necrotizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into the pancreas is sufficient to prevent and/or treat fungal contamination in patients with pancreatic necrosis.

Original language	English
Pages (from-to)	2569-2571
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	44
Issue number	9
DOIs	https://doi.org/10.1128/AAC.44.9.2569-2571.2000
State	Published - 2000
Externally published	Yes

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10.1128/AAC.44.9.2569-2571.2000

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title = "Fluconazole penetration into the pancreas",

abstract = "Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis. In human pancreatic tissues, the mean fluconazole concentration was 8.19 ± 3.38 μg/g (96% of the corresponding concentration in serum). In experimental edematous and necrotizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into the pancreas is sufficient to prevent and/or treat fungal contamination in patients with pancreatic necrosis.",

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T1 - Fluconazole penetration into the pancreas

AU - Shrikhande, S.

AU - Friess, H.

AU - Issenegger, C.

AU - Martignoni, M. E.

AU - Yong, H.

AU - Gloor, B.

AU - Yeates, R.

AU - Kleeff, J.

AU - Buchler, M. W.

PY - 2000

Y1 - 2000

N2 - Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis. In human pancreatic tissues, the mean fluconazole concentration was 8.19 ± 3.38 μg/g (96% of the corresponding concentration in serum). In experimental edematous and necrotizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into the pancreas is sufficient to prevent and/or treat fungal contamination in patients with pancreatic necrosis.

AB - Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis. In human pancreatic tissues, the mean fluconazole concentration was 8.19 ± 3.38 μg/g (96% of the corresponding concentration in serum). In experimental edematous and necrotizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into the pancreas is sufficient to prevent and/or treat fungal contamination in patients with pancreatic necrosis.

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DO - 10.1128/AAC.44.9.2569-2571.2000

M3 - Article

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AN - SCOPUS:0033836294

SN - 0066-4804

VL - 44

SP - 2569

EP - 2571

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

ER -

Fluconazole penetration into the pancreas

Abstract

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