TY - JOUR
T1 - Flow-driven control of pulse width in excitable media
AU - Misselwitz, Adrian Paul
AU - Lafon, Suzanne
AU - Julien, Jean Daniel
AU - Alim, Karen
N1 - Publisher Copyright:
© 2023 authors. Published by the American Physical Society.
PY - 2023/5
Y1 - 2023/5
N2 - Models of pulse formation in nerve conduction have provided manifold insight not only into neuronal dynamics but also the nonlinear dynamics of pulse formation in general. Recent observation of neuronal electrochemical pulses also driving mechanical deformation of the tubular neuronal wall, and thereby generating ensuing cytoplasmic flow, now question the impact of flow on the electrochemical dynamics of pulse formation. Here, we theoretically investigate the classical Fitzhugh-Nagumo model, now accounting for advective coupling between the pulse propagator typically describing membrane potential and triggering mechanical deformations, and thus governing flow magnitude, and the pulse controller, a chemical species advected with the ensuing fluid flow. Employing analytical calculations and numerical simulations, we find that advective coupling allows for a linear control of pulse width while leaving pulse velocity unchanged. We therefore uncover an independent control of pulse width by fluid flow coupling.
AB - Models of pulse formation in nerve conduction have provided manifold insight not only into neuronal dynamics but also the nonlinear dynamics of pulse formation in general. Recent observation of neuronal electrochemical pulses also driving mechanical deformation of the tubular neuronal wall, and thereby generating ensuing cytoplasmic flow, now question the impact of flow on the electrochemical dynamics of pulse formation. Here, we theoretically investigate the classical Fitzhugh-Nagumo model, now accounting for advective coupling between the pulse propagator typically describing membrane potential and triggering mechanical deformations, and thus governing flow magnitude, and the pulse controller, a chemical species advected with the ensuing fluid flow. Employing analytical calculations and numerical simulations, we find that advective coupling allows for a linear control of pulse width while leaving pulse velocity unchanged. We therefore uncover an independent control of pulse width by fluid flow coupling.
UR - http://www.scopus.com/inward/record.url?scp=85161345213&partnerID=8YFLogxK
U2 - 10.1103/PhysRevE.107.054218
DO - 10.1103/PhysRevE.107.054218
M3 - Article
AN - SCOPUS:85161345213
SN - 2470-0045
VL - 107
JO - Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
JF - Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
IS - 5
M1 - 054218
ER -