FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements

Jörg Weimer; M. Kiechle; N. Arnold

doi:10.1159/000015502

FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements

Jörg Weimer, M. Kiechle, N. Arnold

Christian-Albrechts-University of Kiel

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We combined the techniques of fluorescence in situ hybridization (FISH) and chromosomal microdissection in one experiment (FISH-MD). This novel method permits rapid identification of the composition, origin, and breakpoints of rearranged chromosomes. Rearranged chromosomes are first identified by multicolor-FISH, then the fluorophore-labeled derivative chromosomes are directly isolated by microdissection and reverse painted to identify the breakpoints. Copyright (C) 2000 S. Karger AG, Basel.

Original language	English
Pages (from-to)	114-118
Number of pages	5
Journal	Cytogenetics and Cell Genetics
Volume	88
Issue number	1-2
DOIs	https://doi.org/10.1159/000015502
State	Published - 2000
Externally published	Yes

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title = "FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements",

abstract = "We combined the techniques of fluorescence in situ hybridization (FISH) and chromosomal microdissection in one experiment (FISH-MD). This novel method permits rapid identification of the composition, origin, and breakpoints of rearranged chromosomes. Rearranged chromosomes are first identified by multicolor-FISH, then the fluorophore-labeled derivative chromosomes are directly isolated by microdissection and reverse painted to identify the breakpoints. Copyright (C) 2000 S. Karger AG, Basel.",

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AB - We combined the techniques of fluorescence in situ hybridization (FISH) and chromosomal microdissection in one experiment (FISH-MD). This novel method permits rapid identification of the composition, origin, and breakpoints of rearranged chromosomes. Rearranged chromosomes are first identified by multicolor-FISH, then the fluorophore-labeled derivative chromosomes are directly isolated by microdissection and reverse painted to identify the breakpoints. Copyright (C) 2000 S. Karger AG, Basel.

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FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements

Abstract

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