FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements

Jörg Weimer, M. Kiechle, N. Arnold

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We combined the techniques of fluorescence in situ hybridization (FISH) and chromosomal microdissection in one experiment (FISH-MD). This novel method permits rapid identification of the composition, origin, and breakpoints of rearranged chromosomes. Rearranged chromosomes are first identified by multicolor-FISH, then the fluorophore-labeled derivative chromosomes are directly isolated by microdissection and reverse painted to identify the breakpoints. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)114-118
Number of pages5
JournalCytogenetics and Cell Genetics
Issue number1-2
StatePublished - 2000
Externally publishedYes


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