TY - GEN
T1 - First phantom and in vivo MPI images with an extended field of view
AU - Schmale, I.
AU - Rahmer, J.
AU - Gleich, B.
AU - Kanzenbach, J.
AU - Schmidt, J. D.
AU - Bontus, C.
AU - Woywode, O.
AU - Borgert, J.
PY - 2011
Y1 - 2011
N2 - Magnetic Particle Imaging (MPI) is a high-potential new medical imaging modality that has been introduced in 2005. MPI uses the non-linear magnetization behavior of iron-oxide based nano-particles, named tracer, to perform quantitative measurements of their local concentration. Previous publications demonstrated the feasibility of real-time in vivo 3D imaging with clinical concentration of Resovist®. Given MPI's fast and sensitive imaging as well as its overall versatility, it has potential to support various medical applications spanning from diagnostics to therapy. As an example, ongoing research investigates the use of MPI in cardiovascular diagnostics for myocardial perfusion measurement. While previous publications reported results from experimental systems with limited bore size (3cm), this contribution presents first phantom and in vivo images acquired on the next hardware generation, an experimental system with an effective bore size of 12cm. The system is designed for pre-clinical studies and can capture image data from an extended field of view compared to the previous, experimental system. The contribution introduces concepts for the encoding of a larger field of view by means of additional magnetic fields, named focus-fields, and outlines the path to stitching of images from multiple focus field settings, called "multi-station reconstruction". To prove the feasibility of imaging of an extended field of view, volumetric images of a moving phantom as well as of a living rat were acquired.
AB - Magnetic Particle Imaging (MPI) is a high-potential new medical imaging modality that has been introduced in 2005. MPI uses the non-linear magnetization behavior of iron-oxide based nano-particles, named tracer, to perform quantitative measurements of their local concentration. Previous publications demonstrated the feasibility of real-time in vivo 3D imaging with clinical concentration of Resovist®. Given MPI's fast and sensitive imaging as well as its overall versatility, it has potential to support various medical applications spanning from diagnostics to therapy. As an example, ongoing research investigates the use of MPI in cardiovascular diagnostics for myocardial perfusion measurement. While previous publications reported results from experimental systems with limited bore size (3cm), this contribution presents first phantom and in vivo images acquired on the next hardware generation, an experimental system with an effective bore size of 12cm. The system is designed for pre-clinical studies and can capture image data from an extended field of view compared to the previous, experimental system. The contribution introduces concepts for the encoding of a larger field of view by means of additional magnetic fields, named focus-fields, and outlines the path to stitching of images from multiple focus field settings, called "multi-station reconstruction". To prove the feasibility of imaging of an extended field of view, volumetric images of a moving phantom as well as of a living rat were acquired.
KW - Focus field
KW - Magnetic nano-particles
KW - Magnetic particle imaging
KW - MPI
KW - Multi-station reconstruction
UR - http://www.scopus.com/inward/record.url?scp=79955844665&partnerID=8YFLogxK
U2 - 10.1117/12.877339
DO - 10.1117/12.877339
M3 - Conference contribution
AN - SCOPUS:79955844665
SN - 9780819485076
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2011
T2 - Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
Y2 - 13 February 2011 through 16 February 2011
ER -