First efficient palladium-catalyzed Heck reactions of aryl bromides with alkyl methacrylate

Matthias Beller, Thomas H. Riermeier

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

An efficient palladium-catalyzed coupling reactions of aryl bromides with butyl methacrylate has been developed. Depending on the reaction conditions various amounts of butyl 3-aryl-2-methylpropenoate and butyl 3-aryl-2-methyliden-propenoate as well as double arylated products were produced. Superior turn over numbers up to 8300 and turn over frequencies up to 1000 h-1 for Heck reactions of aryl bromides with methacrylic acid ester have been obtained for the first time.

Original languageEnglish
Pages (from-to)6535-6538
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number36
DOIs
StatePublished - 2 Sep 1996
Externally publishedYes

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