Fiaud's Acid: A Brønsted Acid Catalyst for Enantioselective Friedel-Crafts Alkylation of Indoles with 2-Alkene-1,4-diones

Keyphrases

• Alkenes 100%
• Enantioselectivity 100%
• Acid Catalyst 100%
• 4-dione 100%
• Alkylation of Indole 100%
• Friedel-Crafts Alkylation 100%
• Brønsted Acid 100%
• Recrystallization 33%
• Room Temperature 33%
• Butane 33%
• Reaction Conditions 33%
• Phospholanes 33%
• High Enantioselectivity 33%
• Trans-1 33%
• Oxides 33%
• Catalyst Loading 33%
• 1-butene 33%
• 2-Butene 33%
• Indol 33%
• Intramolecular Friedel-Crafts Acylation 33%
• Complex Target 33%
• Phosphinic Acid 33%

Chemistry

• Alkene 100%
• Acid Catalyst 100%
• Indole 100%
• Friedel-Crafts Alkylation 100%
• Ambient Reaction Temperature 50%
• Phospholane 50%
• Enantioselectivity 50%
• Phosphinic Acid 50%
• Butene 50%