Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain

Alexandra A. Blak, Thorsten Naserke, Jonna Saarimäki-Vire, Paula Peltopuro, Mario Giraldo-Velasquez, Daniela M. Vogt Weisenhorn, Nilima Prakash, Michael Sendtner, Juha Partanen, Wolfgang Wurst

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The mid-/hindbrain organizer (MHO) is characterized by the expression of a network of genes, which controls the patterning and development of the prospective midbrain and anterior hindbrain. One key molecule acting at the MHO is the fibroblast growth factor (Fgf) 8. Ectopic expression of Fgf8 induces genes that are normally expressed at the mid-/hindbrain boundary followed by the induction of midbrain and anterior hindbrain structures. Inactivation of the Fgf receptor (Fgfr) 1 gene, which was thought to be the primary transducer of the Fgf8 signal at the MHO, in the mid-/hindbrain region, leads to a deletion of dorsal structures of the mid-/hindbrain region, whereas ventral tissues are less severely affected. This suggests that other Fgfrs might be responsible for ventral mid-/hindbrain region development. Here we report the analysis of Fgfr2 conditional knockout mice, lacking the Fgfr2 in the mid-/hindbrain region and of Fgfr3 knockout mice with respect to the mid-/hindbrain region. In both homozygous mouse mutants, patterning of the mid-/hindbrain region is not altered, neuronal populations develop normal and are maintained into adulthood. This analysis shows that the Fgfr2 and the Fgfr3 on their own are dispensable for the development of the mid-/hindbrain region. We suggest functional redundancy of Fgf receptors in the mid-/hindbrain region.

Original languageEnglish
Pages (from-to)231-243
Number of pages13
JournalDevelopmental Biology
Volume303
Issue number1
DOIs
StatePublished - 1 Mar 2007
Externally publishedYes

Keywords

  • Fgf signaling
  • Fibroblast growth factor receptor
  • Functional redundancy
  • Hindbrain
  • Midbrain

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