TY - JOUR
T1 - Feasibility of nTMS-based DTI fiber tracking of language pathways in neurosurgical patients using a fractional anisotropy threshold
AU - Sollmann, Nico
AU - Negwer, Chiara
AU - Ille, Sebastian
AU - Maurer, Stefanie
AU - Hauck, Theresa
AU - Kirschke, Jan S.
AU - Ringel, Florian
AU - Meyer, Bernhard
AU - Krieg, Sandro M.
N1 - Publisher Copyright:
© 2016 Elsevier B.V..
PY - 2016/7/15
Y1 - 2016/7/15
N2 - Background: Navigated transcranial magnetic stimulation (nTMS) provides language maps in brain tumor patients. Yet, corresponding data on the visualization of language-related subcortical pathways is lacking. Therefore, this study evaluates the feasibility of nTMS-based diffusion tensor imaging fiber tracking (DTI FT) for subcortical language pathways by a fractional anisotropy (FA) protocol. New method: DTI FT was performed in 37 patients suffering from left-sided perisylvian brain lesions based on nTMS data exclusively, using the FA-based protocol originally established for the corticospinal tract (CST) by Frey et al. (2012): minimum fiber length was 110 mm and the highest individual FA value leading to visualization of white matter tracts was determined as the FA threshold (FAT). Then, deterministic DTI FT using an FA value of 100%, 75%, 50%, and 25% of the individual FAT (with 25% as an additional setting to the original protocol) was performed. Results: Our approach visualized 9 language-related subcortical white matter pathways. By using 100% FAT, the mean percentage of visualized tracts was 13.5%, whereas DTI FT performed with 75%, 50%, and 25% FAT detected 30.6%, 61.3%, and 93.7% of language-related fiber tracts, respectively. Comparison with existing methods: nTMS language mapping alone is not able to visualize subcortical language-related pathways. Conclusions: This study shows that nTMS language maps are feasible for DTI FT of language-related pathways within the scope of a FAT-based protocol. Although this approach is novel and might be helpful during scientific neuroimaging and tumor resection, intraoperative validation is needed to go beyond the level of feasibility.
AB - Background: Navigated transcranial magnetic stimulation (nTMS) provides language maps in brain tumor patients. Yet, corresponding data on the visualization of language-related subcortical pathways is lacking. Therefore, this study evaluates the feasibility of nTMS-based diffusion tensor imaging fiber tracking (DTI FT) for subcortical language pathways by a fractional anisotropy (FA) protocol. New method: DTI FT was performed in 37 patients suffering from left-sided perisylvian brain lesions based on nTMS data exclusively, using the FA-based protocol originally established for the corticospinal tract (CST) by Frey et al. (2012): minimum fiber length was 110 mm and the highest individual FA value leading to visualization of white matter tracts was determined as the FA threshold (FAT). Then, deterministic DTI FT using an FA value of 100%, 75%, 50%, and 25% of the individual FAT (with 25% as an additional setting to the original protocol) was performed. Results: Our approach visualized 9 language-related subcortical white matter pathways. By using 100% FAT, the mean percentage of visualized tracts was 13.5%, whereas DTI FT performed with 75%, 50%, and 25% FAT detected 30.6%, 61.3%, and 93.7% of language-related fiber tracts, respectively. Comparison with existing methods: nTMS language mapping alone is not able to visualize subcortical language-related pathways. Conclusions: This study shows that nTMS language maps are feasible for DTI FT of language-related pathways within the scope of a FAT-based protocol. Although this approach is novel and might be helpful during scientific neuroimaging and tumor resection, intraoperative validation is needed to go beyond the level of feasibility.
KW - Cortical mapping
KW - Diffusion tensor imaging
KW - Fiber tracking
KW - Language
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=84963956120&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2016.04.002
DO - 10.1016/j.jneumeth.2016.04.002
M3 - Article
C2 - 27059128
AN - SCOPUS:84963956120
SN - 0165-0270
VL - 267
SP - 45
EP - 54
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
ER -