Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Filippo Calzolari; Julia Michel; Emily Violette Baumgart; Fabian Theis; Magdalena Götz; Jovica Ninkovic

doi:10.1038/nn.3963

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Filippo Calzolari, Julia Michel, Emily Violette Baumgart, Fabian Theis, Magdalena Götz, Jovica Ninkovic

Chair of Mathematical Modelling of Biological Systems

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

Original language	English
Pages (from-to)	490-492
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	4
DOIs	https://doi.org/10.1038/nn.3963
State	Published - 28 Apr 2015

Access to Document

10.1038/nn.3963

Cite this

@article{444a5fd6212d414a94d1223a400201e6,

title = "Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone",

abstract = "We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.",

author = "Filippo Calzolari and Julia Michel and Baumgart, {Emily Violette} and Fabian Theis and Magdalena G{\"o}tz and Jovica Ninkovic",

year = "2015",

month = apr,

day = "28",

doi = "10.1038/nn.3963",

language = "English",

volume = "18",

pages = "490--492",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "4",

}

TY - JOUR

T1 - Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

AU - Calzolari, Filippo

AU - Michel, Julia

AU - Baumgart, Emily Violette

AU - Theis, Fabian

AU - Götz, Magdalena

AU - Ninkovic, Jovica

PY - 2015/4/28

Y1 - 2015/4/28

N2 - We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

AB - We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

UR - http://www.scopus.com/inward/record.url?scp=84925779543&partnerID=8YFLogxK

U2 - 10.1038/nn.3963

DO - 10.1038/nn.3963

M3 - Article

C2 - 25730673

AN - SCOPUS:84925779543

SN - 1097-6256

VL - 18

SP - 490

EP - 492

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 4

ER -

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Abstract

Access to Document

Other files and links

Fingerprint

Cite this