Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Filippo Calzolari, Julia Michel, Emily Violette Baumgart, Fabian Theis, Magdalena Götz, Jovica Ninkovic

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

Original languageEnglish
Pages (from-to)490-492
Number of pages3
JournalNature Neuroscience
Volume18
Issue number4
DOIs
StatePublished - 28 Apr 2015

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