Familial and Genetic Factors of Restless Legs Syndrome

J. Winkelmann

doi:10.1016/B978-0-12-378610-4.00383-1

Familial and Genetic Factors of Restless Legs Syndrome

J. Winkelmann

Chair of Neurogenetics (2015 — 2023)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Restless legs syndrome (RLS) is a common sleep-related movement disorder with heritability estimates of about 50%. RLS is a complex genetic disorder where genetic and environmental factors are contributing to the phenotype. Population-based association studies have identified genomic loci containing causally related genes. Their role in RLS pathophysiology still remains to be determined and will shed light on the etiology of the disease in near future.

Original language	English
Title of host publication	Encyclopedia of Sleep
Publisher	Elsevier Inc.
Pages	22-28
Number of pages	7
ISBN (Electronic)	9780123786111
ISBN (Print)	9780123786104
DOIs	https://doi.org/10.1016/B978-0-12-378610-4.00383-1
State	Published - 1 Jan 2013

Keywords

Genetics
Genome-wide association study (GWA)
Linkage analysis
Restless legs syndrome

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10.1016/B978-0-12-378610-4.00383-1

Cite this

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KW - Linkage analysis

KW - Restless legs syndrome

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PB - Elsevier Inc.

ER -

Familial and Genetic Factors of Restless Legs Syndrome

Abstract

Keywords

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