Facile three-component coupling procedure for the synthesis of substituted tetrahydroisoindole-1,3-diones from α,β-unsaturated aldehydes

Axel Jacobi Von Wangelin, Helfried Neumann, Dirk Gördes, Anke Spannenberg, Matthias Beller

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

(equation presented) A new one-pot procedure for the efficient synthesis of a small library of amino-functionalized tetrahydroisoindole-1,3-dione derivatives was developed. This three-component coupling reaction comprises subsequent condensation and Diels-Alder reactions of ubiquitous available starting materials (α,β-unsaturated aldehydes, amide, and maleimide). The synthesized compounds share a substituted tetrahydroisoindole motif in an endo fashion.

Original languageEnglish
Pages (from-to)2895-2898
Number of pages4
JournalOrganic Letters
Volume3
Issue number18
DOIs
StatePublished - 6 Sep 2001
Externally publishedYes

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