Facile and scalable preparation of 2-imidazolylpyridines

Andreas Raba; Markus R. Anneser; Dominik Jantke; Mirza Cokoja; Wolfgang A. Herrmann; Fritz E. Kühn

doi:10.1016/j.tetlet.2013.04.060

Facile and scalable preparation of 2-imidazolylpyridines

Andreas Raba, Markus R. Anneser, Dominik Jantke, Mirza Cokoja, Wolfgang A. Herrmann, Fritz E. Kühn

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A novel method for the synthesis of 2-imidazolylpyridines is presented. The reaction of 2-halopyridines, potassium carbonate, and imidazole at high temperatures under inert gas atmosphere leads exclusively to the formation of 2-imidazolylpyridines in high yields. The synthesis is scalable, comparatively inexpensive, and the products are easily isolable.

Original language	English
Pages (from-to)	3384-3387
Number of pages	4
Journal	Tetrahedron Letters
Volume	54
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2013.04.060
State	Published - 26 Jun 2013

Keywords

2-Imidazolylpyridine
Metal free coupling
Nucleophilic aromatic substitution
Solvent free synthesis

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10.1016/j.tetlet.2013.04.060

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title = "Facile and scalable preparation of 2-imidazolylpyridines",

abstract = "A novel method for the synthesis of 2-imidazolylpyridines is presented. The reaction of 2-halopyridines, potassium carbonate, and imidazole at high temperatures under inert gas atmosphere leads exclusively to the formation of 2-imidazolylpyridines in high yields. The synthesis is scalable, comparatively inexpensive, and the products are easily isolable.",

keywords = "2-Imidazolylpyridine, Metal free coupling, Nucleophilic aromatic substitution, Solvent free synthesis",

author = "Andreas Raba and Anneser, {Markus R.} and Dominik Jantke and Mirza Cokoja and Herrmann, {Wolfgang A.} and K{\"u}hn, {Fritz E.}",

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T1 - Facile and scalable preparation of 2-imidazolylpyridines

AU - Raba, Andreas

AU - Anneser, Markus R.

AU - Jantke, Dominik

AU - Cokoja, Mirza

AU - Herrmann, Wolfgang A.

AU - Kühn, Fritz E.

PY - 2013/6/26

Y1 - 2013/6/26

N2 - A novel method for the synthesis of 2-imidazolylpyridines is presented. The reaction of 2-halopyridines, potassium carbonate, and imidazole at high temperatures under inert gas atmosphere leads exclusively to the formation of 2-imidazolylpyridines in high yields. The synthesis is scalable, comparatively inexpensive, and the products are easily isolable.

AB - A novel method for the synthesis of 2-imidazolylpyridines is presented. The reaction of 2-halopyridines, potassium carbonate, and imidazole at high temperatures under inert gas atmosphere leads exclusively to the formation of 2-imidazolylpyridines in high yields. The synthesis is scalable, comparatively inexpensive, and the products are easily isolable.

KW - 2-Imidazolylpyridine

KW - Metal free coupling

KW - Nucleophilic aromatic substitution

KW - Solvent free synthesis

UR - http://www.scopus.com/inward/record.url?scp=84878406100&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2013.04.060

DO - 10.1016/j.tetlet.2013.04.060

M3 - Article

AN - SCOPUS:84878406100

SN - 0040-4039

VL - 54

SP - 3384

EP - 3387

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

Facile and scalable preparation of 2-imidazolylpyridines

Abstract

Keywords

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