Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors

Georg Dultz, Tetsuro Shimakami, Markus Schneider, Kazuhisa Murai, Daisuke Yamane, Antoine Marion, Tobias M. Zeitler, Claudia Stross, Christian Grimm, Rebecca M. Richter, Katrin Bäumer, Min Kyung Yi, Ricardo M. Biondi, Stefan Zeuzem, Robert Tampé, Iris Antes, Christian M. Lange, Christoph Welsch

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Biochemistry, Genetics and Molecular Biology