Expression of the hepatitis B surface antigen (HbsAg) under the control of mMT-I promoter in transgenic mice can be induced by zinc sulphate, dexamethasone and lipopolysaccharide

C. Anastassiadis; O. Rottmann; S. Hörmansdorfer; F. Pirchner

doi:10.1111/j.1439-0388.1997.tb00508.x

Expression of the hepatitis B surface antigen (HbsAg) under the control of mMT-I promoter in transgenic mice can be induced by zinc sulphate, dexamethasone and lipopolysaccharide

C. Anastassiadis, O. Rottmann, S. Hörmansdorfer, F. Pirchner

Life Sciences

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

Abstract

Metallothionein genes can be induced in vivo by heavy metals, glucocorticoids, and toxins. In all transgenic mice carrying the MT-I promoter, that have been reported so far, induction by glucocorticoids failed. This study reports two mouse lines, transgenic for the murine MT-I-HBV (hepatitis B virus; map position site: 30-1986) construct, which secrete the viral surface antigen (HBsAg) in their serum. In both lines, males produce more HBsAg than females, and in all cases the MT-I promoter can be induced by dexamethasone, lipopolysaccharide (LPS), and heavy metals. A glucocorticoid-responsive element, which is situated in the HBV fragment used, can explain the dexamethasone induction of the MT-I promoter.

Original language	English
Pages (from-to)	225-230
Number of pages	6
Journal	Journal of Animal Breeding and Genetics
Volume	114
Issue number	3
DOIs	https://doi.org/10.1111/j.1439-0388.1997.tb00508.x
State	Published - 1997

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10.1111/j.1439-0388.1997.tb00508.x

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title = "Expression of the hepatitis B surface antigen (HbsAg) under the control of mMT-I promoter in transgenic mice can be induced by zinc sulphate, dexamethasone and lipopolysaccharide",

abstract = "Metallothionein genes can be induced in vivo by heavy metals, glucocorticoids, and toxins. In all transgenic mice carrying the MT-I promoter, that have been reported so far, induction by glucocorticoids failed. This study reports two mouse lines, transgenic for the murine MT-I-HBV (hepatitis B virus; map position site: 30-1986) construct, which secrete the viral surface antigen (HBsAg) in their serum. In both lines, males produce more HBsAg than females, and in all cases the MT-I promoter can be induced by dexamethasone, lipopolysaccharide (LPS), and heavy metals. A glucocorticoid-responsive element, which is situated in the HBV fragment used, can explain the dexamethasone induction of the MT-I promoter.",

author = "C. Anastassiadis and O. Rottmann and S. H{\"o}rmansdorfer and F. Pirchner",

year = "1997",

doi = "10.1111/j.1439-0388.1997.tb00508.x",

language = "English",

volume = "114",

pages = "225--230",

journal = "Journal of Animal Breeding and Genetics",

issn = "0931-2668",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

Anastassiadis, C, Rottmann, O, Hörmansdorfer, S & Pirchner, F 1997, 'Expression of the hepatitis B surface antigen (HbsAg) under the control of mMT-I promoter in transgenic mice can be induced by zinc sulphate, dexamethasone and lipopolysaccharide', Journal of Animal Breeding and Genetics, vol. 114, no. 3, pp. 225-230. https://doi.org/10.1111/j.1439-0388.1997.tb00508.x

Expression of the hepatitis B surface antigen (HbsAg) under the control of mMT-I promoter in transgenic mice can be induced by zinc sulphate, dexamethasone and lipopolysaccharide. / Anastassiadis, C.; Rottmann, O.; Hörmansdorfer, S. et al.
In: Journal of Animal Breeding and Genetics, Vol. 114, No. 3, 1997, p. 225-230.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Expression of the hepatitis B surface antigen (HbsAg) under the control of mMT-I promoter in transgenic mice can be induced by zinc sulphate, dexamethasone and lipopolysaccharide

AU - Anastassiadis, C.

AU - Rottmann, O.

AU - Hörmansdorfer, S.

AU - Pirchner, F.

PY - 1997

Y1 - 1997

N2 - Metallothionein genes can be induced in vivo by heavy metals, glucocorticoids, and toxins. In all transgenic mice carrying the MT-I promoter, that have been reported so far, induction by glucocorticoids failed. This study reports two mouse lines, transgenic for the murine MT-I-HBV (hepatitis B virus; map position site: 30-1986) construct, which secrete the viral surface antigen (HBsAg) in their serum. In both lines, males produce more HBsAg than females, and in all cases the MT-I promoter can be induced by dexamethasone, lipopolysaccharide (LPS), and heavy metals. A glucocorticoid-responsive element, which is situated in the HBV fragment used, can explain the dexamethasone induction of the MT-I promoter.

AB - Metallothionein genes can be induced in vivo by heavy metals, glucocorticoids, and toxins. In all transgenic mice carrying the MT-I promoter, that have been reported so far, induction by glucocorticoids failed. This study reports two mouse lines, transgenic for the murine MT-I-HBV (hepatitis B virus; map position site: 30-1986) construct, which secrete the viral surface antigen (HBsAg) in their serum. In both lines, males produce more HBsAg than females, and in all cases the MT-I promoter can be induced by dexamethasone, lipopolysaccharide (LPS), and heavy metals. A glucocorticoid-responsive element, which is situated in the HBV fragment used, can explain the dexamethasone induction of the MT-I promoter.

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U2 - 10.1111/j.1439-0388.1997.tb00508.x

DO - 10.1111/j.1439-0388.1997.tb00508.x

M3 - Article

AN - SCOPUS:0031527744

SN - 0931-2668

VL - 114

SP - 225

EP - 230

JO - Journal of Animal Breeding and Genetics

JF - Journal of Animal Breeding and Genetics

IS - 3

ER -

Expression of the hepatitis B surface antigen (HbsAg) under the control of mMT-I promoter in transgenic mice can be induced by zinc sulphate, dexamethasone and lipopolysaccharide

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