Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum

Achim Berthele; Stefan Platzer; David J. Laurie; Serge Weis; Bernd Sommer; Walter Zieglgänsberger; Bastian Conrad; Thomas R. Tölle

doi:10.1097/00001756-199912160-00026

Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum

Achim Berthele
, Stefan Platzer
, David J. Laurie
, Serge Weis
, Bernd Sommer
, Walter Zieglgänsberger
, Bastian Conrad
, Thomas R. Tölle

Max Planck Institute of Psychiatry
Novartis Pharma AG
Otto-von-Guericke University
Technical University of Munich

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

THE expression of metabotropic glutamate receptor (mGluR) mRNAs in the human cerebellar neocortex was investigated using in situ hybridization, mGluR1, 3 and 4 mRNAs were most abundant and widely distributed, whereas mGluR2, 5 and 7 mRNA expression was circumscript. mRNAs coding for mGluR1, 3, 4 and 7 were expressed in Purkinje cells. mGluR1 and 4 mRNAs detectable in granule cells and mGluR1, 2, 3, 4 and 7 mRNAs in Golgi cells. mGluR5 mRNA was detectable in putative Bergmann glia as well as mGluR3 mRNA, which was widely expressed in glial cells, mGluR8 mRNA expression was very low in a subset of stellate/basket cells of the molecular layer whereas mGluR6 mRNA was not detectable in the cerebellar cortex.

Original language	English
Pages (from-to)	3861-3867
Number of pages	7
Journal	NeuroReport
Volume	10
Issue number	18
DOIs	https://doi.org/10.1097/00001756-199912160-00026
State	Published - 16 Dec 1999

Keywords

Human cerebellum
In situ hybridization
MRNA expression
Metabotropic glutamate receptor
Oligodeoxynucleotide probes

Access to Document

10.1097/00001756-199912160-00026

Cite this

@article{8e46e8e3c4c146919b7b216f05cb908e,

title = "Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum",

abstract = "THE expression of metabotropic glutamate receptor (mGluR) mRNAs in the human cerebellar neocortex was investigated using in situ hybridization, mGluR1, 3 and 4 mRNAs were most abundant and widely distributed, whereas mGluR2, 5 and 7 mRNA expression was circumscript. mRNAs coding for mGluR1, 3, 4 and 7 were expressed in Purkinje cells. mGluR1 and 4 mRNAs detectable in granule cells and mGluR1, 2, 3, 4 and 7 mRNAs in Golgi cells. mGluR5 mRNA was detectable in putative Bergmann glia as well as mGluR3 mRNA, which was widely expressed in glial cells, mGluR8 mRNA expression was very low in a subset of stellate/basket cells of the molecular layer whereas mGluR6 mRNA was not detectable in the cerebellar cortex.",

keywords = "Human cerebellum, In situ hybridization, MRNA expression, Metabotropic glutamate receptor, Oligodeoxynucleotide probes",

author = "Achim Berthele and Stefan Platzer and Laurie, \{David J.\} and Serge Weis and Bernd Sommer and Walter Zieglg{\"a}nsberger and Bastian Conrad and T{\"o}lle, \{Thomas R.\}",

year = "1999",

month = dec,

day = "16",

doi = "10.1097/00001756-199912160-00026",

language = "English",

volume = "10",

pages = "3861--3867",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "18",

}

TY - JOUR

T1 - Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum

AU - Berthele, Achim

AU - Platzer, Stefan

AU - Laurie, David J.

AU - Weis, Serge

AU - Sommer, Bernd

AU - Zieglgänsberger, Walter

AU - Conrad, Bastian

AU - Tölle, Thomas R.

PY - 1999/12/16

Y1 - 1999/12/16

N2 - THE expression of metabotropic glutamate receptor (mGluR) mRNAs in the human cerebellar neocortex was investigated using in situ hybridization, mGluR1, 3 and 4 mRNAs were most abundant and widely distributed, whereas mGluR2, 5 and 7 mRNA expression was circumscript. mRNAs coding for mGluR1, 3, 4 and 7 were expressed in Purkinje cells. mGluR1 and 4 mRNAs detectable in granule cells and mGluR1, 2, 3, 4 and 7 mRNAs in Golgi cells. mGluR5 mRNA was detectable in putative Bergmann glia as well as mGluR3 mRNA, which was widely expressed in glial cells, mGluR8 mRNA expression was very low in a subset of stellate/basket cells of the molecular layer whereas mGluR6 mRNA was not detectable in the cerebellar cortex.

AB - THE expression of metabotropic glutamate receptor (mGluR) mRNAs in the human cerebellar neocortex was investigated using in situ hybridization, mGluR1, 3 and 4 mRNAs were most abundant and widely distributed, whereas mGluR2, 5 and 7 mRNA expression was circumscript. mRNAs coding for mGluR1, 3, 4 and 7 were expressed in Purkinje cells. mGluR1 and 4 mRNAs detectable in granule cells and mGluR1, 2, 3, 4 and 7 mRNAs in Golgi cells. mGluR5 mRNA was detectable in putative Bergmann glia as well as mGluR3 mRNA, which was widely expressed in glial cells, mGluR8 mRNA expression was very low in a subset of stellate/basket cells of the molecular layer whereas mGluR6 mRNA was not detectable in the cerebellar cortex.

KW - Human cerebellum

KW - In situ hybridization

KW - MRNA expression

KW - Metabotropic glutamate receptor

KW - Oligodeoxynucleotide probes

UR - https://www.scopus.com/pages/publications/0033576766

U2 - 10.1097/00001756-199912160-00026

DO - 10.1097/00001756-199912160-00026

M3 - Article

C2 - 10716224

AN - SCOPUS:0033576766

SN - 0959-4965

VL - 10

SP - 3861

EP - 3867

JO - NeuroReport

JF - NeuroReport

IS - 18

ER -

Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this