Expression of Delta1 and Serrate1 (Jagged 1) in the mouse inner ear

Alastair Morrison, Christine Hodgetts, Achim Gossler, Martin Hrabé De Angelis, Julian Lewis

Research output: Contribution to journalArticlepeer-review

176 Scopus citations

Abstract

The Notch signalling pathway is thought to play a key part in controlling the production of sensory hair cells in the vertebrate inner ear via lateral inhibition; but there is disagreement as to which Notch ligands are expressed in hair cells as they develop. We show, using a mouse Delta1:LacZ knock-in as a reporter, that nascent hair cells, but not their neighbours, express Delta1. Expression of Serrate1 (Jagged1), meanwhile becomes restricted to the supporting cells of each sensory patch. Delta1 is also expressed: (a) at early stages, at the site of otic neurogenesis; and (b) in scattered cells of the endolymphatic sac, as is Serrate1.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalMechanisms of Development
Volume84
Issue number1-2
DOIs
StatePublished - 1 Jun 1999
Externally publishedYes

Keywords

  • Cochlea
  • Crista
  • Delta1
  • Endolymphatic sac
  • Hair cell
  • Inner ear
  • Jagged1
  • Macula
  • Mouse
  • Neurogenesis
  • Notch signalling
  • Sensory patch
  • Serrate1
  • Supporting cell

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