Exposure-lag-response associations between extreme environmental conditions and primary Sjögren’s syndrome

Introduction: Patients with primary Sjögren’s syndrome (pSS) reportedly believe that their symptoms worsen on extreme weather days due to variations in environmental conditions. However, few studies have assessed the acute effects of environmental exposure on the onset of pSS. This study aimed to evaluate the exposure–response relationship between extreme environmental conditions and pSS outpatient visits. Method: We obtained data on pSS outpatient visits from two provincial general hospitals in Hefei, China, during 2014–2019. A distributed lag non-linear model was used to estimate the exposure-lag-response relationship between environmental variables and pSS. Results: We detected significant and non-linear associations between extreme environments and pSS. The estimated relative risk (RR) for a lag of 3 days was 1.11 (95% CI: 1.03 to 1.19) for extreme cold and for a lag of 21 days was 1.07 (95% CI: 1.01 to 1.12) for extreme dampness. Long sunshine duration was positively correlated with pSS (lag 11, 1.05, 95% CI: 1.01 to 1.08). Moreover, female patients were more susceptible to these effects. Patients older than 65 years old were more vulnerable to frigid environments (lag 3, RR = 1.30, 95% CI: 1.09 to 1.54), while younger patients were more vulnerable to extreme dampness (lag 21, RR = 1.10, 95% CI: 1.03 to 1.16). Extreme cold and high humidity were negatively correlated with the same-day outpatient visits. Conclusions: Our findings suggest a potential relationship between exposure to extreme environmental conditions and increased risk of pSS outpatient visits. We therefore suggest that policymakers and doctors aim to further our understanding of environmental effects on pSS and adopt adequate measures to alleviate pSS symptoms.Key Points• Extreme cold, extreme dampness, and long sunshine duration increased the risk of pSS outpatient visits, especially for females.• Young pSS patients are more susceptible to a rise in humidity.• Elderly pSS patients are more sensitive to extreme cold weather.