TY - JOUR
T1 - Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
AU - Sadegh, Sepideh
AU - Matschinske, Julian
AU - Blumenthal, David B.
AU - Galindez, Gihanna
AU - Kacprowski, Tim
AU - List, Markus
AU - Nasirigerdeh, Reza
AU - Oubounyt, Mhaned
AU - Pichlmair, Andreas
AU - Rose, Tim Daniel
AU - Salgado-Albarrán, Marisol
AU - Späth, Julian
AU - Stukalov, Alexey
AU - Wenke, Nina K.
AU - Yuan, Kevin
AU - Pauling, Josch K.
AU - Baumbach, Jan
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/.
AB - Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/.
UR - http://www.scopus.com/inward/record.url?scp=85087993661&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-17189-2
DO - 10.1038/s41467-020-17189-2
M3 - Article
C2 - 32665542
AN - SCOPUS:85087993661
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3518
ER -