Exploiting blind matrix decomposition techniques to identify diagnostic marker genes

Reinhard Schachtner, Dominik Lutter, Fabian J. Theis, Elmar W. Lang, Ana Maria Tomé, Gerd Schmitz

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Exploratory matrix factorization methods like ICA and LNMF are applied to identify marker genes and classify gene expression data sets into different categories for diagnostic purposes or group genes into functional categories for further investigation of related regulatory pathways. Gene expression levels of either human breast cancer (HBC) cell lines [5] mediating bone metastasis or cell lines from Niemann Pick C patients monitoring monocyte - macrophage differentiation are considered.

Original languageEnglish
Title of host publicationArtificial Neural Networks - ICANN 2007 - 17th International Conference, Proceedings
PublisherSpringer Verlag
Pages80-89
Number of pages10
EditionPART 2
ISBN (Print)9783540746935
DOIs
StatePublished - 2007
Externally publishedYes
Event17th International Conference on Artificial Neural Networks, ICANN 2007 - Porto, Portugal
Duration: 9 Sep 200713 Sep 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume4669 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference17th International Conference on Artificial Neural Networks, ICANN 2007
Country/TerritoryPortugal
CityPorto
Period9/09/0713/09/07

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