Experimentell induziertes Pankreascarcinom nach Choledochojejunostomie

K. Rückert; E. Klink; G. Klöppel

doi:10.1007/BF01317612

Experimentell induziertes Pankreascarcinom nach Choledochojejunostomie

Translated title of the contribution: Experimental induced pancreatic carcinoma after choledochojejunostomy

K. Rückert
, E. Klink
, G. Klöppel

University Medical Center
Universität Hamburg

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The pancreatic carcinogen DHPN (dihydroxypropylnitrosamin) was administered to Syrian golden hamsters. By intragastric administration more pancreatic carcinomas in the head of the gland were induced than by subcutaneous injections. After choledochojejunostomy the incidence of carcinomas was only 5 - 7% and the lesions were similar in multiplicity and distribution without relationship to the way of administration. The importance of biliary reflux in pancreatic tumor induction is discussed and the role of bile concerning the preferred localisation of the tumors in the head of the pancreas.

Translated title of the contribution	Experimental induced pancreatic carcinoma after choledochojejunostomy
Original language	German
Pages (from-to)	261-268
Number of pages	8
Journal	Langenbecks Archiv fur Chirurgie
Volume	348
Issue number	4
DOIs	https://doi.org/10.1007/BF01317612
State	Published - Dec 1979
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1007/BF01317612

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title = "Experimentell induziertes Pankreascarcinom nach Choledochojejunostomie",

abstract = "The pancreatic carcinogen DHPN (dihydroxypropylnitrosamin) was administered to Syrian golden hamsters. By intragastric administration more pancreatic carcinomas in the head of the gland were induced than by subcutaneous injections. After choledochojejunostomy the incidence of carcinomas was only 5 - 7\% and the lesions were similar in multiplicity and distribution without relationship to the way of administration. The importance of biliary reflux in pancreatic tumor induction is discussed and the role of bile concerning the preferred localisation of the tumors in the head of the pancreas.",

keywords = "Bile reflux, Nitrosamine, Pancreatic carcinoma",

author = "K. R{\"u}ckert and E. Klink and G. Kl{\"o}ppel",

year = "1979",

month = dec,

doi = "10.1007/BF01317612",

language = "Deutsch",

volume = "348",

pages = "261--268",

journal = "Langenbecks Archiv fur Chirurgie",

issn = "0023-8236",

publisher = "Springer Verlag",

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}

TY - JOUR

T1 - Experimentell induziertes Pankreascarcinom nach Choledochojejunostomie

AU - Rückert, K.

AU - Klink, E.

AU - Klöppel, G.

PY - 1979/12

Y1 - 1979/12

N2 - The pancreatic carcinogen DHPN (dihydroxypropylnitrosamin) was administered to Syrian golden hamsters. By intragastric administration more pancreatic carcinomas in the head of the gland were induced than by subcutaneous injections. After choledochojejunostomy the incidence of carcinomas was only 5 - 7% and the lesions were similar in multiplicity and distribution without relationship to the way of administration. The importance of biliary reflux in pancreatic tumor induction is discussed and the role of bile concerning the preferred localisation of the tumors in the head of the pancreas.

AB - The pancreatic carcinogen DHPN (dihydroxypropylnitrosamin) was administered to Syrian golden hamsters. By intragastric administration more pancreatic carcinomas in the head of the gland were induced than by subcutaneous injections. After choledochojejunostomy the incidence of carcinomas was only 5 - 7% and the lesions were similar in multiplicity and distribution without relationship to the way of administration. The importance of biliary reflux in pancreatic tumor induction is discussed and the role of bile concerning the preferred localisation of the tumors in the head of the pancreas.

KW - Bile reflux

KW - Nitrosamine

KW - Pancreatic carcinoma

UR - https://www.scopus.com/pages/publications/0018777085

U2 - 10.1007/BF01317612

DO - 10.1007/BF01317612

M3 - Artikel

C2 - 226820

AN - SCOPUS:0018777085

SN - 0023-8236

VL - 348

SP - 261

EP - 268

JO - Langenbecks Archiv fur Chirurgie

JF - Langenbecks Archiv fur Chirurgie

IS - 4

ER -

Experimentell induziertes Pankreascarcinom nach Choledochojejunostomie

Abstract

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