Experimentell induziertes Pankreascarcinom nach Choledochojejunostomie

Translated title of the contribution: Experimental induced pancreatic carcinoma after choledochojejunostomy

K. Rückert, E. Klink, G. Klöppel

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The pancreatic carcinogen DHPN (dihydroxypropylnitrosamin) was administered to Syrian golden hamsters. By intragastric administration more pancreatic carcinomas in the head of the gland were induced than by subcutaneous injections. After choledochojejunostomy the incidence of carcinomas was only 5 - 7% and the lesions were similar in multiplicity and distribution without relationship to the way of administration. The importance of biliary reflux in pancreatic tumor induction is discussed and the role of bile concerning the preferred localisation of the tumors in the head of the pancreas.

Translated title of the contributionExperimental induced pancreatic carcinoma after choledochojejunostomy
Original languageGerman
Pages (from-to)261-268
Number of pages8
JournalLangenbecks Archiv für Chirurgie
Issue number4
StatePublished - Dec 1979
Externally publishedYes


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