Experimental fluorescence tomography of tissues with noncontact measurements

Ralf B. Schulz, Jorge Ripoll, Vasilis Ntziachristos

Research output: Contribution to journalArticlepeer-review

194 Scopus citations

Abstract

Noncontact optical measurements from diffuse media could facilitate the use of large detector arrays at multiple angles that are well suited for diffuse optical tomography applications. Such imaging strategy could eliminate the need for individual fibers in contact with tissue, restricted geometries, and matching fluids. Thus, it could significantly improve experimental procedures and enhance our ability to visualize functional and molecular processes in vivo. In this paper, we describe the experimental implementation of this novel concept and demonstrate capacity to perform small animal imaging.

Original languageEnglish
Pages (from-to)492-500
Number of pages9
JournalIEEE Transactions on Medical Imaging
Volume23
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

Keywords

  • Biomedical imaging
  • Optical fluorescence tomography

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