Experimental characterization and simulation of amino acid and peptide interactions with inorganic materials

Sebastian Schwaminger, Silvia Angela Blank-Shim, Monika Borkowska-Panek, Priya Anand, Paula Fraga-García, Karin Fink, Wolfgang Wenzel, Sonja Berensmeier

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Inspired by nature, many applications and new materials benefit from the interplay of inorganic materials and biomolecules. A fundamental understanding of complex organic–inorganic interactions would improve the controlled production of nanomaterials and biosensors to the development of biocompatible implants for the human body. Although widely exploited in applications, the interaction of amino acids and peptides with most inorganic surfaces is not fully understood. To date, precisely characterizing complex surfaces of inorganic materials and analyzing surface–biomolecule interactions remain challenging both experimentally and computationally. This article reviews several approaches to characterizing biomolecule–surface interactions and illustrates the advantages and disadvantages of the methods presented. First, we explain how the adsorption mechanism of amino acids/peptides to inorganic surfaces can be determined and how thermodynamic and kinetic process constants can be obtained. Second, we demonstrate how this data can be used to develop models for peptide–surface interactions. The understanding and simulation of such interactions constitute a basis for developing molecules with high affinity binding domains in proteins for bioprocess engineering and future biomedical technologies.

Original languageEnglish
Pages (from-to)84-100
Number of pages17
JournalEngineering in Life Sciences
Volume18
Issue number2
DOIs
StatePublished - Feb 2018

Keywords

  • Adsorption
  • Amino acid
  • Inorganic surface
  • Interaction
  • Peptide

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