Excess electron transport through DNA: A single electron repairs more than one UV-induced lesion

Bernd Giese; Barbara Carl; Thomas Carl; Thomas Carell; Christoph Behrens; Ulrich Hennecke; Olav Schiemann; Emiliano Feresin

doi:10.1002/anie.200353264

Excess electron transport through DNA: A single electron repairs more than one UV-induced lesion

Bernd Giese
, Barbara Carl
, Thomas Carl
, Thomas Carell
, Christoph Behrens
, Ulrich Hennecke
, Olav Schiemann
, Emiliano Feresin

University of Basel
Philipps-Universität Marburg
Johann Wolfgang Goethe University

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Site-selective injection of a single electron into thymine (yellow) through the modified nucleoside 1 (1→2) was used to examine the dependence of excess electron transfer in DNA on distance. The DNA was cleaved upon arrival of the electron at a thymine dimer (red). This assay showed that one electron can repair more than one UV-induced lesion in DNA 3.

Original language	English
Pages (from-to)	1848-1851
Number of pages	4
Journal	Angewandte Chemie International Edition in English
Volume	43
Issue number	14
DOIs	https://doi.org/10.1002/anie.200353264
State	Published - 26 Mar 2004
Externally published	Yes

Keywords

DNA damage
ESR spectroscopy
Electron transfer
Nucleotides
Radical ions

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10.1002/anie.200353264

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abstract = "Site-selective injection of a single electron into thymine (yellow) through the modified nucleoside 1 (1→2) was used to examine the dependence of excess electron transfer in DNA on distance. The DNA was cleaved upon arrival of the electron at a thymine dimer (red). This assay showed that one electron can repair more than one UV-induced lesion in DNA 3.",

keywords = "DNA damage, ESR spectroscopy, Electron transfer, Nucleotides, Radical ions",

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T2 - A single electron repairs more than one UV-induced lesion

AU - Giese, Bernd

AU - Carl, Barbara

AU - Carl, Thomas

AU - Carell, Thomas

AU - Behrens, Christoph

AU - Hennecke, Ulrich

AU - Schiemann, Olav

AU - Feresin, Emiliano

PY - 2004/3/26

Y1 - 2004/3/26

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AB - Site-selective injection of a single electron into thymine (yellow) through the modified nucleoside 1 (1→2) was used to examine the dependence of excess electron transfer in DNA on distance. The DNA was cleaved upon arrival of the electron at a thymine dimer (red). This assay showed that one electron can repair more than one UV-induced lesion in DNA 3.

KW - DNA damage

KW - ESR spectroscopy

KW - Electron transfer

KW - Nucleotides

KW - Radical ions

UR - https://www.scopus.com/pages/publications/4344593471

U2 - 10.1002/anie.200353264

DO - 10.1002/anie.200353264

M3 - Article

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AN - SCOPUS:4344593471

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JF - Angewandte Chemie International Edition in English

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ER -

Excess electron transport through DNA: A single electron repairs more than one UV-induced lesion

Abstract

Keywords

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