TY - GEN
T1 - Exact synthesis of biomolecular protocols for multiple sample pathways on digital microfluidic biochips
AU - Keszocze, Oliver
AU - Ibrahim, Mohamed
AU - Wille, Robert
AU - Chakrabarty, Krishnendu
AU - Drechsler, Rolf
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/3/27
Y1 - 2018/3/27
N2 - Digital-microfluidic biochips (DMFBs) allow laboratory steps associated with genomic bioassays to be carried out in an automated and highly efficient fashion. However, to support complex (multi-sample) biomolecular protocols for quantitative analysis, conventional design-Automation methods are ineffective, thereby motivating the need for more suitable solutions. While first methods to address this problem have recently been introduced, they neglect architectural details and technology-related constraints, and use heuristics to oversimplify the search for a design solution. These simplifications result in designs that may either not be realizable on a DMFB or it is not possible to evaluate how far they are from being optimal. In this work, we propose an exact synthesis method that does not rely on simplistic models and heuristics, but solves the underlying design problem in an exact fashion. The proposed method allows for the determination of exact and realistic results for the realization of quantitative-Analysis biomolecular protocols on DMFBs.
AB - Digital-microfluidic biochips (DMFBs) allow laboratory steps associated with genomic bioassays to be carried out in an automated and highly efficient fashion. However, to support complex (multi-sample) biomolecular protocols for quantitative analysis, conventional design-Automation methods are ineffective, thereby motivating the need for more suitable solutions. While first methods to address this problem have recently been introduced, they neglect architectural details and technology-related constraints, and use heuristics to oversimplify the search for a design solution. These simplifications result in designs that may either not be realizable on a DMFB or it is not possible to evaluate how far they are from being optimal. In this work, we propose an exact synthesis method that does not rely on simplistic models and heuristics, but solves the underlying design problem in an exact fashion. The proposed method allows for the determination of exact and realistic results for the realization of quantitative-Analysis biomolecular protocols on DMFBs.
KW - Biomolecular protocols
KW - Dmfb
KW - Microfluidics
KW - Resource allocation
UR - http://www.scopus.com/inward/record.url?scp=85046757741&partnerID=8YFLogxK
U2 - 10.1109/VLSID.2018.48
DO - 10.1109/VLSID.2018.48
M3 - Conference contribution
AN - SCOPUS:85046757741
T3 - Proceedings of the IEEE International Conference on VLSI Design
SP - 121
EP - 126
BT - Proceedings - 31st International Conference on VLSI Design, VLSID 2018 - Held concurrently with 17th International Conference on Embedded Systems, ES 2018
PB - IEEE Computer Society
T2 - 31st International Conference on VLSI Design, VLSID 2018
Y2 - 6 January 2018 through 10 January 2018
ER -