Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

Sandra Nischwitz, Sabine Cepok, Antje Kroner, Christiane Wolf, Matthias Knop, Felix Müller-Sarnowski, Hildegard Pfister, Darina Roeske, Peter Rieckmann, Bernhard Hemmer, Marcus Ising, Manfred Uhr, Thomas Bettecken, Florian Holsboer, Bertram Müller-Myhsok, Frank Weber

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalJournal of Neuroimmunology
Volume227
Issue number1-2
DOIs
StatePublished - Oct 2010

Keywords

  • Association study
  • Multiple sclerosis
  • Susceptibility genes
  • VAV2
  • ZNF433

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