Abstract
In 18 patients who were treated with combined regional hyperthermia and radiation for recurrent pelvic tumors, blood flow related data were obtained using dynamic computed tomography and dynamic magnetic resonance imaging. The enhancement of contrast material (Δ HU) and Gadolinium DTPA (Δ SI) over baseline in the early phase (15-30 s) after bolus injection is dependent upon perfusion. With both methods significant differences in global perfusion have been observed between tumor center and tumor periphery. With regard to the mean perfusion values we are able to separate high, medium and low perfused pelvic tumors. Flow rates expressed as Δ HU for dynamic CT and Δ SI for dynamic MRI show a significant inverse correlation with the achieved steady state temperatures above baseline. Values of enhancement of contrast material higher than 15-35 Δ HU or 300-700 Δ SI indicate flow rates which were limiting in achieving steady state temperatures higher than 3°C above baseline (core temperature).
Original language | English |
---|---|
Pages (from-to) | 224-229 |
Number of pages | 6 |
Journal | European Journal of Radiology |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - Apr 1993 |
Externally published | Yes |
Keywords
- Blood flow dynamics
- Computed tomography, technique
- Hyperthermia
- Magnetic resonance, technique