Evaluation of tumor blood perfusion by dynamic MRI and CT in patients undergoing thermoradiotherapy

Horst Jürgen Feldmann, Klaus Sievers, Jürgen Füller, Michale Molls, Eberhard Löhr

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

In 18 patients who were treated with combined regional hyperthermia and radiation for recurrent pelvic tumors, blood flow related data were obtained using dynamic computed tomography and dynamic magnetic resonance imaging. The enhancement of contrast material (Δ HU) and Gadolinium DTPA (Δ SI) over baseline in the early phase (15-30 s) after bolus injection is dependent upon perfusion. With both methods significant differences in global perfusion have been observed between tumor center and tumor periphery. With regard to the mean perfusion values we are able to separate high, medium and low perfused pelvic tumors. Flow rates expressed as Δ HU for dynamic CT and Δ SI for dynamic MRI show a significant inverse correlation with the achieved steady state temperatures above baseline. Values of enhancement of contrast material higher than 15-35 Δ HU or 300-700 Δ SI indicate flow rates which were limiting in achieving steady state temperatures higher than 3°C above baseline (core temperature).

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalEuropean Journal of Radiology
Volume16
Issue number3
DOIs
StatePublished - Apr 1993
Externally publishedYes

Keywords

  • Blood flow dynamics
  • Computed tomography, technique
  • Hyperthermia
  • Magnetic resonance, technique

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