Evaluation of the kinin-induced pathomechanisms in the development of ARDS by kallikrein inhibition in vivo.

O. Thetter; H. Hoffmann; M. Siebeck; H. F. Welter; H. Fritz

Evaluation of the kinin-induced pathomechanisms in the development of ARDS by kallikrein inhibition in vivo.

O. Thetter, H. Hoffmann, M. Siebeck, H. F. Welter, H. Fritz

Department of Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Our findings indicate that the kallikrein-kinin system might participate in the development of acute respiratory failure. They were assessed by measurements of plasma kininogen levels, blood pressure recordings and lung morphology. Aprotinin plasma concentrations ranging from 4 to 7 KIU/ml proved sufficient to inhibit effectively the hemodynamic and morphologic effects caused by tissue kallikrein infusion.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Progress in clinical and biological research
Volume	236 A
State	Published - 1987

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@article{fcd97471075147579d433c44a053f25a,

title = "Evaluation of the kinin-induced pathomechanisms in the development of ARDS by kallikrein inhibition in vivo.",

abstract = "Our findings indicate that the kallikrein-kinin system might participate in the development of acute respiratory failure. They were assessed by measurements of plasma kininogen levels, blood pressure recordings and lung morphology. Aprotinin plasma concentrations ranging from 4 to 7 KIU/ml proved sufficient to inhibit effectively the hemodynamic and morphologic effects caused by tissue kallikrein infusion.",

author = "O. Thetter and H. Hoffmann and M. Siebeck and Welter, \{H. F.\} and H. Fritz",

year = "1987",

language = "English",

volume = "236 A",

pages = "127--131",

journal = "Progress in clinical and biological research",

issn = "0361-7742",

publisher = "John Wiley \& Sons Inc.",

}

TY - JOUR

T1 - Evaluation of the kinin-induced pathomechanisms in the development of ARDS by kallikrein inhibition in vivo.

AU - Thetter, O.

AU - Hoffmann, H.

AU - Siebeck, M.

AU - Welter, H. F.

AU - Fritz, H.

PY - 1987

Y1 - 1987

N2 - Our findings indicate that the kallikrein-kinin system might participate in the development of acute respiratory failure. They were assessed by measurements of plasma kininogen levels, blood pressure recordings and lung morphology. Aprotinin plasma concentrations ranging from 4 to 7 KIU/ml proved sufficient to inhibit effectively the hemodynamic and morphologic effects caused by tissue kallikrein infusion.

AB - Our findings indicate that the kallikrein-kinin system might participate in the development of acute respiratory failure. They were assessed by measurements of plasma kininogen levels, blood pressure recordings and lung morphology. Aprotinin plasma concentrations ranging from 4 to 7 KIU/ml proved sufficient to inhibit effectively the hemodynamic and morphologic effects caused by tissue kallikrein infusion.

UR - https://www.scopus.com/pages/publications/0023072630

M3 - Article

C2 - 2441403

AN - SCOPUS:0023072630

SN - 0361-7742

VL - 236 A

SP - 127

EP - 131

JO - Progress in clinical and biological research

JF - Progress in clinical and biological research

ER -

Evaluation of the kinin-induced pathomechanisms in the development of ARDS by kallikrein inhibition in vivo.

Abstract

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