Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)

Sabine Guth; Matthias Baum; Alexander T. Cartus; Patrick Diel; Karl Heinz Engel; Barbara Engeli; Bernd Epe; Tilman Grune; Dirk Haller; Volker Heinz; Michael Hellwig; Jan G. Hengstler; Thomas Henle; Hans Ulrich Humpf; Henry Jäger; Hans Georg Joost; Sabine E. Kulling; Dirk W. Lachenmeier; Alfonso Lampen; Marcel Leist; Angela Mally; Doris Marko; Ute Nöthlings; Elke Röhrdanz; Angelika Roth; Joachim Spranger; Richard Stadler; Pablo Steinberg; Stefan Vieths; Wim Wätjen; Gerhard Eisenbrand

doi:10.1016/j.fct.2023.113632

Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)

Sabine Guth, Matthias Baum, Alexander T. Cartus, Patrick Diel, Karl Heinz Engel, Barbara Engeli, Bernd Epe, Tilman Grune, Dirk Haller, Volker Heinz, Michael Hellwig, Jan G. Hengstler, Thomas Henle, Hans Ulrich Humpf, Henry Jäger, Hans Georg Joost, Sabine E. Kulling, Dirk W. Lachenmeier, Alfonso Lampen, Marcel LeistAngela Mally, Doris Marko, Ute Nöthlings, Elke Röhrdanz, Angelika Roth, Joachim Spranger, Richard Stadler, Pablo Steinberg, Stefan Vieths, Wim Wätjen, Gerhard Eisenbrand

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

This opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated risk assessment of diet-related exposure to acrylamide (AA), based on a critical review of scientific evidence relevant to low dose exposure. The SKLM arrives at the conclusion that as long as an appropriate exposure limit for AA is not exceeded, genotoxic effects resulting in carcinogenicity are unlikely to occur. Based on the totality of the evidence, the SKLM considers it scientifically justified to derive a tolerable daily intake (TDI) as a health-based guidance value.

Original language	English
Article number	113632
Journal	Food and Chemical Toxicology
Volume	173
DOIs	https://doi.org/10.1016/j.fct.2023.113632
State	Published - Mar 2023

Keywords

Acrylamide
Genotoxic carcinogen
Non-linear dose response
Risk assessment
Thresholded MoA
Tolerable daily intake

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10.1016/j.fct.2023.113632

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Guth, S., Baum, M., Cartus, A. T., Diel, P., Engel, K. H., Engeli, B., Epe, B., Grune, T., Haller, D., Heinz, V., Hellwig, M., Hengstler, J. G., Henle, T., Humpf, H. U., Jäger, H., Joost, H. G., Kulling, S. E., Lachenmeier, D. W., Lampen, A., ... Eisenbrand, G. (2023). Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value). Food and Chemical Toxicology, 173, Article 113632. https://doi.org/10.1016/j.fct.2023.113632

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title = "Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)",

abstract = "This opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated risk assessment of diet-related exposure to acrylamide (AA), based on a critical review of scientific evidence relevant to low dose exposure. The SKLM arrives at the conclusion that as long as an appropriate exposure limit for AA is not exceeded, genotoxic effects resulting in carcinogenicity are unlikely to occur. Based on the totality of the evidence, the SKLM considers it scientifically justified to derive a tolerable daily intake (TDI) as a health-based guidance value.",

keywords = "Acrylamide, Genotoxic carcinogen, Non-linear dose response, Risk assessment, Thresholded MoA, Tolerable daily intake",

author = "Sabine Guth and Matthias Baum and Cartus, {Alexander T.} and Patrick Diel and Engel, {Karl Heinz} and Barbara Engeli and Bernd Epe and Tilman Grune and Dirk Haller and Volker Heinz and Michael Hellwig and Hengstler, {Jan G.} and Thomas Henle and Humpf, {Hans Ulrich} and Henry J{\"a}ger and Joost, {Hans Georg} and Kulling, {Sabine E.} and Lachenmeier, {Dirk W.} and Alfonso Lampen and Marcel Leist and Angela Mally and Doris Marko and Ute N{\"o}thlings and Elke R{\"o}hrdanz and Angelika Roth and Joachim Spranger and Richard Stadler and Pablo Steinberg and Stefan Vieths and Wim W{\"a}tjen and Gerhard Eisenbrand",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = mar,

doi = "10.1016/j.fct.2023.113632",

language = "English",

volume = "173",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

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Guth, S, Baum, M, Cartus, AT, Diel, P, Engel, KH, Engeli, B, Epe, B, Grune, T, Haller, D, Heinz, V, Hellwig, M, Hengstler, JG, Henle, T, Humpf, HU, Jäger, H, Joost, HG, Kulling, SE, Lachenmeier, DW, Lampen, A, Leist, M, Mally, A, Marko, D, Nöthlings, U, Röhrdanz, E, Roth, A, Spranger, J, Stadler, R, Steinberg, P, Vieths, S, Wätjen, W & Eisenbrand, G 2023, 'Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)', Food and Chemical Toxicology, vol. 173, 113632. https://doi.org/10.1016/j.fct.2023.113632

TY - JOUR

T1 - Evaluation of the genotoxic potential of acrylamide

T2 - Arguments for the derivation of a tolerable daily intake (TDI value)

AU - Guth, Sabine

AU - Baum, Matthias

AU - Cartus, Alexander T.

AU - Diel, Patrick

AU - Engel, Karl Heinz

AU - Engeli, Barbara

AU - Epe, Bernd

AU - Grune, Tilman

AU - Haller, Dirk

AU - Heinz, Volker

AU - Hellwig, Michael

AU - Hengstler, Jan G.

AU - Henle, Thomas

AU - Humpf, Hans Ulrich

AU - Jäger, Henry

AU - Joost, Hans Georg

AU - Kulling, Sabine E.

AU - Lachenmeier, Dirk W.

AU - Lampen, Alfonso

AU - Leist, Marcel

AU - Mally, Angela

AU - Marko, Doris

AU - Nöthlings, Ute

AU - Röhrdanz, Elke

AU - Roth, Angelika

AU - Spranger, Joachim

AU - Stadler, Richard

AU - Steinberg, Pablo

AU - Vieths, Stefan

AU - Wätjen, Wim

AU - Eisenbrand, Gerhard

PY - 2023/3

Y1 - 2023/3

N2 - This opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated risk assessment of diet-related exposure to acrylamide (AA), based on a critical review of scientific evidence relevant to low dose exposure. The SKLM arrives at the conclusion that as long as an appropriate exposure limit for AA is not exceeded, genotoxic effects resulting in carcinogenicity are unlikely to occur. Based on the totality of the evidence, the SKLM considers it scientifically justified to derive a tolerable daily intake (TDI) as a health-based guidance value.

AB - This opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated risk assessment of diet-related exposure to acrylamide (AA), based on a critical review of scientific evidence relevant to low dose exposure. The SKLM arrives at the conclusion that as long as an appropriate exposure limit for AA is not exceeded, genotoxic effects resulting in carcinogenicity are unlikely to occur. Based on the totality of the evidence, the SKLM considers it scientifically justified to derive a tolerable daily intake (TDI) as a health-based guidance value.

KW - Acrylamide

KW - Genotoxic carcinogen

KW - Non-linear dose response

KW - Risk assessment

KW - Thresholded MoA

KW - Tolerable daily intake

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U2 - 10.1016/j.fct.2023.113632

DO - 10.1016/j.fct.2023.113632

M3 - Review article

C2 - 36708862

AN - SCOPUS:85147260051

SN - 0278-6915

VL - 173

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

M1 - 113632

ER -

Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)

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Keywords

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