Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity

Carsten Nieder; Lu Cai; Wolfgang A. Weber; Sabine Schill; Nicolaus Andratschke; Markus Schwaiger; Michael Molls

Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity

Carsten Nieder, Lu Cai, Wolfgang A. Weber, Sabine Schill, Nicolaus Andratschke, Markus Schwaiger, Michael Molls

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated ^99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment. In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.

Original language	English
Pages (from-to)	183-188
Number of pages	6
Journal	Anticancer Research
Volume	27
Issue number	1 A
State	Published - Jan 2007

Keywords

Insulin-like growth factor-1
Kidney
Radiation tolerance
Radiotherapy

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abstract = "The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated 99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment. In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.",

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AU - Nieder, Carsten

AU - Cai, Lu

AU - Weber, Wolfgang A.

AU - Schill, Sabine

AU - Andratschke, Nicolaus

AU - Schwaiger, Markus

AU - Molls, Michael

PY - 2007/1

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N2 - The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated 99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment. In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.

AB - The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated 99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment. In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.

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KW - Kidney

KW - Radiation tolerance

KW - Radiotherapy

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Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity

Abstract

Keywords

UN SDGs

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