Evaluating the signal processing chain employed in surface plasmon resonance biosensing

Tiago A.T. De Sousa, L. C. Oliveira, F. C.C. Loureiro, Antonio M.N. Lima, H. Neff

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

10 Scopus citations

Abstract

The optical biosensor based on the Surface Plasmon Resonance phenomenon is, today, the most accurate and sensible label free biosensor. However, this high sensitivity of the SPR biosensor systems has a side effect: a high sensitivity to noise present all over the system. The ambient temperature, the position of the components, the impurities in the light path, the photo detector instrumentation, are all noise sources that can degrade the information present in the signal. Preprocessing this signal before extracting the interest parameters and even the techniques used to extract these parameters can minimize the degradation effect of the noise. This paper proposes a study to determine the best techniques to be applied that most reduces the noise degradation. A combination of techniques can improve the results or just increase the complexity with no gain in noise elimination. An influence in the techniques sequence has also influenced the result, being necessary to determine the best sequence. Also to tune the technique parameters to the optimal, a miss tuning may preserve noise that can be removed or can eliminate precious information with the noise, degenerating the signal. The paper also aims at determining the best technique combination to be applied in parameter extraction.

Original languageEnglish
Title of host publication2014 IEEE International Instrumentation and Measurement Technology Conference
Subtitle of host publicationInstrumentation and Measurement for Sustainable Development, I2MTC 2014 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1606-1611
Number of pages6
ISBN (Print)9781467363853
DOIs
StatePublished - 2014
Externally publishedYes
Event2014 IEEE International Instrumentation and Measurement Technology Conference: Instrumentation and Measurement for Sustainable Development, I2MTC 2014 - Montevideo, Uruguay
Duration: 12 May 201415 May 2014

Publication series

NameConference Record - IEEE Instrumentation and Measurement Technology Conference
ISSN (Print)1091-5281

Conference

Conference2014 IEEE International Instrumentation and Measurement Technology Conference: Instrumentation and Measurement for Sustainable Development, I2MTC 2014
Country/TerritoryUruguay
CityMontevideo
Period12/05/1415/05/14

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