TY - JOUR
T1 - European evidence-based guidelines on pancreatic cystic neoplasms
AU - The European Study Group on Cystic Tumours of the Pancreas
AU - Del Chiaro, Marco
AU - Besselink, Marc G.
AU - Scholten, Lianne
AU - Bruno, Marco J.
AU - Cahen, Djuna L.
AU - Gress, Thomas M.
AU - van Hooft, Jeanin E.
AU - Lerch, Markus M.
AU - Mayerle, Julia
AU - Hackert, Thilo
AU - Satoi, Sohei
AU - Zerbi, Alessandro
AU - Cunningham, David
AU - De Angelis, Claudio
AU - Giovannini, Marc
AU - de-Madaria, Enrique
AU - Hegyi, Peter
AU - Rosendahl, Jonas
AU - Friess, Helmut
AU - Manfredi, Riccardo
AU - Lévy, Philippe
AU - Real, Francisco X.
AU - Sauvanet, Alain
AU - Hilal, Mohammed Abu
AU - Marchegiani, Giovanni
AU - Esposito, Irene
AU - Ghaneh, Paula
AU - Engelbrecht, Marc R.W.
AU - Fockens, Paul
AU - van Huijgevoort, Nadine C.M.
AU - Wolfgang, Christopher
AU - Bassi, Claudio
AU - Gubergrits, Natalya B.
AU - Verbeke, Caroline
AU - Klöppel, Günter
AU - Scarpa, Aldo
AU - Zamboni, Giuseppe
AU - Lennon, Anne Marie
AU - Sund, Malin
AU - Kartalis, Nikolaos
AU - Grenacher, Lars
AU - Falconi, Massimo
AU - Arnelo, Urban
AU - Kopchak, Kostantin V.
AU - Oppong, Kofi
AU - McKay, Colin
AU - Hauge, Truls
AU - Conlon, Kevin
AU - Adham, Mustapha
AU - Ceyhan, Güralp O.
N1 - Publisher Copyright:
© Article author(s) 2018. All rights reserved.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring <40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter ≥40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule >5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.
AB - Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring <40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter ≥40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule >5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.
UR - http://www.scopus.com/inward/record.url?scp=85046420272&partnerID=8YFLogxK
U2 - 10.1136/gutjnl-2018-316027
DO - 10.1136/gutjnl-2018-316027
M3 - Review article
C2 - 29574408
AN - SCOPUS:85046420272
SN - 0017-5749
VL - 67
SP - 789
EP - 804
JO - Gut
JF - Gut
IS - 5
ER -