Abstract
A first example of an Et2Zn mediated silylation of 1-aklynes is reported. A series of functional groups are tolerated in this reaction. Mechanistic studies support Zn alkynilides as intermediates in the reaction. This reaction protocol provides a practical method for the preparation of alkynylsilanes and expands the application of organometallic zinc in organic synthesis.
Original language | English |
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Pages (from-to) | 1574-1577 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 60 |
Issue number | 24 |
DOIs | |
State | Published - 13 Jun 2019 |
Keywords
- 1-Alkynes
- Alkynylsilanes
- C(sp)-H silylation
- EtZn-mediated