Et2Zn-mediated stoichiometric C(sp)-H silylation of 1-alkynes and chlorosilanes

Pan Huang, Dawen Xu, Robert M. Reich, Felix Kaiser, Boping Liu, Fritz E. Kühn

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A first example of an Et2Zn mediated silylation of 1-aklynes is reported. A series of functional groups are tolerated in this reaction. Mechanistic studies support Zn alkynilides as intermediates in the reaction. This reaction protocol provides a practical method for the preparation of alkynylsilanes and expands the application of organometallic zinc in organic synthesis.

Original languageEnglish
Pages (from-to)1574-1577
Number of pages4
JournalTetrahedron Letters
Volume60
Issue number24
DOIs
StatePublished - 13 Jun 2019

Keywords

  • 1-Alkynes
  • Alkynylsilanes
  • C(sp)-H silylation
  • EtZn-mediated

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