TY - JOUR
T1 - Etiology and site of temporal lobe epilepsy influence postictal cytokine release
AU - Bauer, Sebastian
AU - Cepok, Sabine
AU - Todorova-Rudolph, Anelia
AU - Nowak, Mareike
AU - Köller, Martina
AU - Lorenz, Rüdiger
AU - Oertel, Wolfgang H.
AU - Rosenow, Felix
AU - Hemmer, Bernhard
AU - Hamer, Hajo M.
PY - 2009/9
Y1 - 2009/9
N2 - Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1β, IL-6 and TNFα in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying factors. Serum levels of IL-1β, IL-6 and TNFα were quantified by ELISA at baseline as well as immediately, 1 h and 24 h after a complex partial (CPS) or secondary generalized tonic-clonic seizure (GTCS) during video-EEG monitoring in 25 patients suffering from temporal epilepsy. IL-6 increased by 51% immediately after the seizure (p < 0.01) and remained elevated for 24 h. This increase lacked in patients with hippocampal sclerosis (HS; n = 16, mean increase 28%, p > 0.5, vs. 112%, p < 0.01 in patients without HS). IL-6 levels were higher after right-sided seizures as compared to left-sided seizures 24 h after the seizure (8.7 pg/mL vs. 3.4 pg/mL, p < 0.05). In patients taking valproate (VPA, n = 9), the levels of IL-1β were higher as compared to patients not treated with VPA. The results suggest a relationship between the cytokine system and characteristics of TLE such as side and pathology.
AB - Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1β, IL-6 and TNFα in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying factors. Serum levels of IL-1β, IL-6 and TNFα were quantified by ELISA at baseline as well as immediately, 1 h and 24 h after a complex partial (CPS) or secondary generalized tonic-clonic seizure (GTCS) during video-EEG monitoring in 25 patients suffering from temporal epilepsy. IL-6 increased by 51% immediately after the seizure (p < 0.01) and remained elevated for 24 h. This increase lacked in patients with hippocampal sclerosis (HS; n = 16, mean increase 28%, p > 0.5, vs. 112%, p < 0.01 in patients without HS). IL-6 levels were higher after right-sided seizures as compared to left-sided seizures 24 h after the seizure (8.7 pg/mL vs. 3.4 pg/mL, p < 0.05). In patients taking valproate (VPA, n = 9), the levels of IL-1β were higher as compared to patients not treated with VPA. The results suggest a relationship between the cytokine system and characteristics of TLE such as side and pathology.
KW - Cytokines
KW - IL-1
KW - IL-6
KW - Seizure
KW - TNF-alpha
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=68749098135&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2009.05.009
DO - 10.1016/j.eplepsyres.2009.05.009
M3 - Article
C2 - 19520550
AN - SCOPUS:68749098135
SN - 0920-1211
VL - 86
SP - 82
EP - 88
JO - Epilepsy Research
JF - Epilepsy Research
IS - 1
ER -