Ethanol

Helmut Greim

doi:10.1016/B978-0-12-824315-2.00775-2

Ethanol

Helmut Greim

Former organisations of Medicine and Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Ethanol (CAS: 64-17-5) is a high-volume solvent, chemical manufacturing intermediate, and common ingredient in many consumer products including alcoholic beverages. Chronic overexposure to ethanol can result in hepatotoxicity, neurotoxicity, and developmental toxicity. Ethanol is metabolized very efficiently by alcohol dehydrogenase to acetaldehyde and then by aldehyde dehydrogenase to acetate. There are polymorphic variants of the alcohol dehydrogenase and aldehyde dehydrogenase.

Original language	English
Title of host publication	Encyclopedia of Toxicology, Fourth Edition
Subtitle of host publication	Volume 1-9
Publisher	Elsevier
Pages	V4-407-V4-412
Volume	4
ISBN (Electronic)	9780128243152
DOIs	https://doi.org/10.1016/B978-0-12-824315-2.00775-2
State	Published - 1 Jan 2023

Keywords

Acetaldehyde
Acetate
Fetal alcohol spectrum disorders
Hepatotoxicity
Lipid peroxidation
Malondialdehyde
Neurotoxicity

Access to Document

10.1016/B978-0-12-824315-2.00775-2

Cite this

@inbook{eefb93c57f32440ba97d4ee51fa9bc24,

title = "Ethanol",

abstract = "Ethanol (CAS: 64-17-5) is a high-volume solvent, chemical manufacturing intermediate, and common ingredient in many consumer products including alcoholic beverages. Chronic overexposure to ethanol can result in hepatotoxicity, neurotoxicity, and developmental toxicity. Ethanol is metabolized very efficiently by alcohol dehydrogenase to acetaldehyde and then by aldehyde dehydrogenase to acetate. There are polymorphic variants of the alcohol dehydrogenase and aldehyde dehydrogenase.",

keywords = "Acetaldehyde, Acetate, Fetal alcohol spectrum disorders, Hepatotoxicity, Lipid peroxidation, Malondialdehyde, Neurotoxicity",

author = "Helmut Greim",

year = "2023",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-824315-2.00775-2",

language = "English",

volume = "4",

pages = "V4--407--V4--412",

booktitle = "Encyclopedia of Toxicology, Fourth Edition",

publisher = "Elsevier",

}

TY - CHAP

T1 - Ethanol

AU - Greim, Helmut

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Ethanol (CAS: 64-17-5) is a high-volume solvent, chemical manufacturing intermediate, and common ingredient in many consumer products including alcoholic beverages. Chronic overexposure to ethanol can result in hepatotoxicity, neurotoxicity, and developmental toxicity. Ethanol is metabolized very efficiently by alcohol dehydrogenase to acetaldehyde and then by aldehyde dehydrogenase to acetate. There are polymorphic variants of the alcohol dehydrogenase and aldehyde dehydrogenase.

AB - Ethanol (CAS: 64-17-5) is a high-volume solvent, chemical manufacturing intermediate, and common ingredient in many consumer products including alcoholic beverages. Chronic overexposure to ethanol can result in hepatotoxicity, neurotoxicity, and developmental toxicity. Ethanol is metabolized very efficiently by alcohol dehydrogenase to acetaldehyde and then by aldehyde dehydrogenase to acetate. There are polymorphic variants of the alcohol dehydrogenase and aldehyde dehydrogenase.

KW - Acetaldehyde

KW - Acetate

KW - Fetal alcohol spectrum disorders

KW - Hepatotoxicity

KW - Lipid peroxidation

KW - Malondialdehyde

KW - Neurotoxicity

UR - http://www.scopus.com/inward/record.url?scp=85188105303&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-824315-2.00775-2

DO - 10.1016/B978-0-12-824315-2.00775-2

M3 - Chapter

AN - SCOPUS:85188105303

VL - 4

SP - V4-407-V4-412

BT - Encyclopedia of Toxicology, Fourth Edition

PB - Elsevier

ER -

Ethanol

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this