ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Angela Casini; Guido Mastrobuoni; Wee Han Ang; Chiara Gabbiani; Giuseppe Pieraccini; Gloriano Moneti; Paul J. Dyson; Luigi Messori

doi:10.1002/cmdc.200600258

ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Angela Casini, Guido Mastrobuoni, Wee Han Ang, Chiara Gabbiani, Giuseppe Pieraccini, Gloriano Moneti, Paul J. Dyson, Luigi Messori

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

(Chemical Equation Presented) Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compounds and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metallation was readily obtained.

Original language	English
Pages (from-to)	631-635
Number of pages	5
Journal	ChemMedChem
Volume	2
Issue number	5
DOIs	https://doi.org/10.1002/cmdc.200600258
State	Published - 14 May 2007
Externally published	Yes

Keywords

Anticancer drugs
Complexes
High-resolution ESIMS
Proteins
Ruthenium arene

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10.1002/cmdc.200600258

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abstract = "(Chemical Equation Presented) Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compounds and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metallation was readily obtained.",

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AU - Casini, Angela

AU - Mastrobuoni, Guido

AU - Ang, Wee Han

AU - Gabbiani, Chiara

AU - Pieraccini, Giuseppe

AU - Moneti, Gloriano

AU - Dyson, Paul J.

AU - Messori, Luigi

PY - 2007/5/14

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AB - (Chemical Equation Presented) Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compounds and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metallation was readily obtained.

KW - Anticancer drugs

KW - Complexes

KW - High-resolution ESIMS

KW - Proteins

KW - Ruthenium arene

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ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Abstract

Keywords

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