ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

Angela Casini; Guido Mastrobuoni; Claudia Temperini; Chiara Gabbiani; Simona Francese; Gloriano Moneti; Claudiu T. Supuran; Andrea Scozzafava; Luigi Messori

doi:10.1039/b611122j

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

Angela Casini
, Guido Mastrobuoni
, Claudia Temperini
, Chiara Gabbiani
, Simona Francese
, Gloriano Moneti
, Claudiu T. Supuran
, Andrea Scozzafava
, Luigi Messori

University of Florence

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.

Original language	English
Pages (from-to)	156-158
Number of pages	3
Journal	Chemical Communications
Issue number	2
DOIs	https://doi.org/10.1039/b611122j
State	Published - 2007
Externally published	Yes

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10.1039/b611122j

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title = "ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme",

abstract = "The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 {\AA} resolution, reveals selective platination of imidazole Nε of His15.",

author = "Angela Casini and Guido Mastrobuoni and Claudia Temperini and Chiara Gabbiani and Simona Francese and Gloriano Moneti and Supuran, \{Claudiu T.\} and Andrea Scozzafava and Luigi Messori",

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doi = "10.1039/b611122j",

language = "English",

pages = "156--158",

journal = "Chemical Communications",

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T1 - ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

AU - Casini, Angela

AU - Mastrobuoni, Guido

AU - Temperini, Claudia

AU - Gabbiani, Chiara

AU - Francese, Simona

AU - Moneti, Gloriano

AU - Supuran, Claudiu T.

AU - Scozzafava, Andrea

AU - Messori, Luigi

PY - 2007

Y1 - 2007

N2 - The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.

AB - The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.

UR - https://www.scopus.com/pages/publications/33845741247

U2 - 10.1039/b611122j

DO - 10.1039/b611122j

M3 - Article

C2 - 17180231

AN - SCOPUS:33845741247

SN - 1359-7345

SP - 156

EP - 158

JO - Chemical Communications

JF - Chemical Communications

IS - 2

ER -

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

Abstract

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