ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

Angela Casini, Guido Mastrobuoni, Claudia Temperini, Chiara Gabbiani, Simona Francese, Gloriano Moneti, Claudiu T. Supuran, Andrea Scozzafava, Luigi Messori

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.

Original languageEnglish
Pages (from-to)156-158
Number of pages3
JournalChemical Communications
Issue number2
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Dive into the research topics of 'ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme'. Together they form a unique fingerprint.

Cite this