Abstract
The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.
Original language | English |
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Pages (from-to) | 156-158 |
Number of pages | 3 |
Journal | Chemical Communications |
Issue number | 2 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |