TY - JOUR
T1 - Erythrocyte indexes, iron metabolism, and hyperhomocysteinemia in adults with cyanotic congenital cardiac disease
AU - Kaemmerer, Harald
AU - Fratz, Sohrab
AU - Braun, Siegfried L.
AU - Koelling, Klaus
AU - Eicken, Andreas
AU - Brodherr-Heberlein, Silke
AU - Pietrzik, Klaus
AU - Hess, John
PY - 2004/9/15
Y1 - 2004/9/15
N2 - A high percentage of cyanotic adults (37%) with cyanotic congenital cardiac disease (CCD) presented with depleted iron stores (13 of 52) or latent iron deficiency (6 of 52), even in a CCD center in which cyanotic patient phlebotomy is mostly avoided. In many of these patients, hypochromia and microcytosis was frequent, whereas hyperchromia and macrocytosis were relatively common.Furthermore, 50% of patients presented with hyperhomocysteinemia, possibly related to folate or B vitamin deficiencies, which may increase red blood cell size and color, explaining the lack of microcytosis and hypochromia in many cyanotic patients with iron deficiency.
AB - A high percentage of cyanotic adults (37%) with cyanotic congenital cardiac disease (CCD) presented with depleted iron stores (13 of 52) or latent iron deficiency (6 of 52), even in a CCD center in which cyanotic patient phlebotomy is mostly avoided. In many of these patients, hypochromia and microcytosis was frequent, whereas hyperchromia and macrocytosis were relatively common.Furthermore, 50% of patients presented with hyperhomocysteinemia, possibly related to folate or B vitamin deficiencies, which may increase red blood cell size and color, explaining the lack of microcytosis and hypochromia in many cyanotic patients with iron deficiency.
UR - https://www.scopus.com/pages/publications/4544331930
U2 - 10.1016/j.amjcard.2004.06.014
DO - 10.1016/j.amjcard.2004.06.014
M3 - Article
C2 - 15374802
AN - SCOPUS:4544331930
SN - 0002-9149
VL - 94
SP - 825
EP - 828
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -